Synthetic Cannabinoids and Synthetic Cannabinoid-Induced Psychotic Disorders

Papanti Duccio, Schifano Fabrizio, Orsolini Laura

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Synthetic cannabinoids (SCs) are cannabimimetic compounds that represent a large and diverse class of novel psychoactive substances. SCs can exert full- or even super-agonist activity at cannabinoid receptors, while Δ9-tetrahydrocannabinol (THC), the main psychoactive phytocannabinoid in cannabis, has weak, partial agonist activity at cannabinoid receptors. SCs may therefore have higher addictive liability than natural cannabis. SC consumption has been associated with psychotomimetic effects, the induction of psychotic disorders, and other clinically relevant effects of acute toxicity. These conditions are qualitatively and quantitatively different from those observed after cannabis intake, with SC ingestion also being associated with increasing numbers of confirmed fatalities.

Original languageEnglish
Title of host publicationThe Complex Connection between Cannabis and Schizophrenia
EditorsJoslyn Chiaprasert-Paguio
Place of PublicationLondon
PublisherElsevier
Chapter9
Pages199-220
Number of pages22
ISBN (Electronic)9780128047910
ISBN (Print)9780128051832
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Cannabis
  • Novel psychoactive substances
  • Psychosis
  • Synthetic cannabinoids

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