Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Holly Siddique; Barbara Pendry; M Mukhlesur Rahman

doi:10.3390/molecules24030385

Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Holly Siddique, Barbara Pendry, M Mukhlesur Rahman

Research output: Contribution to journal › Article › peer-review

Abstract

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

Original language	English
Article number	385
Number of pages	10
Journal	Molecules
Volume	24
Issue number	3
DOIs	https://doi.org/10.3390/molecules24030385
Publication status	Published - 22 Jan 2019

Keywords

Anti-Bacterial Agents/chemistry
Drug Evaluation, Preclinical
Drug Resistance, Multiple, Bacterial/drug effects
Humans
Magnetic Resonance Spectroscopy
Methicillin-Resistant Staphylococcus aureus/drug effects
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts/chemistry
Terpenes/chemistry
Zingiberaceae/chemistry

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title = "Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus",

abstract = "Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).",

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author = "Holly Siddique and Barbara Pendry and Rahman, {M Mukhlesur}",

year = "2019",

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doi = "10.3390/molecules24030385",

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T1 - Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

AU - Siddique, Holly

AU - Pendry, Barbara

AU - Rahman, M Mukhlesur

PY - 2019/1/22

Y1 - 2019/1/22

N2 - Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

AB - Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

KW - Anti-Bacterial Agents/chemistry

KW - Drug Evaluation, Preclinical

KW - Drug Resistance, Multiple, Bacterial/drug effects

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Methicillin-Resistant Staphylococcus aureus/drug effects

KW - Microbial Sensitivity Tests

KW - Molecular Structure

KW - Plant Extracts/chemistry

KW - Terpenes/chemistry

KW - Zingiberaceae/chemistry

U2 - 10.3390/molecules24030385

DO - 10.3390/molecules24030385

M3 - Article

C2 - 30678230

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 3

M1 - 385

ER -

Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Abstract

Keywords

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