Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

Holly Siddique

doi:10.1016/j.sciaf.2021.e00751

Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

Holly Siddique

Centre for Research in Mechanisms of Disease and Drug Discovery

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We describe two new terpenoids, 3′',5′'-dihydroxycinnamoyl-3β,28,30-dihydroxylup-20(29)-ene (1) and 6S,9S-dihydroxycasbe-3E,7E,11E-trien-5,10-dione (2) and ten known asperglaucide, aridanin, isoscopoletin, maslinic acid, ursolic acid, oleanolic acid, lupeol, sitosterol, stigmasterol and stigmasterol-glucoside from a West African, Guineo-Congolian mangrove and strand forest tree, Oxystigma mannii (Baill.) Harms. The structures of the new compounds were determined based on their 1D and 2D NMR, HRMS and FTIR. DP4+ probabilities were used to assign the configurations for compound 2. The two compounds were tested for their antimicrobial effects against Saccharomyces cerevisiae (BY4743), Escherichia coli (BW25113) and Bacillus subtilis (BY4743), but no inhibition was observed at the maximum concentrations tested (800 μM).

Original language	English
Journal	Scientific African
Volume	12
DOIs	https://doi.org/10.1016/j.sciaf.2021.e00751
Publication status	Published - 24 Mar 2021

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@article{496da06ddec24418a15f74f59c436358,

title = "Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms",

abstract = "We describe two new terpenoids, 3′',5′'-dihydroxycinnamoyl-3β,28,30-dihydroxylup-20(29)-ene (1) and 6S,9S-dihydroxycasbe-3E,7E,11E-trien-5,10-dione (2) and ten known asperglaucide, aridanin, isoscopoletin, maslinic acid, ursolic acid, oleanolic acid, lupeol, sitosterol, stigmasterol and stigmasterol-glucoside from a West African, Guineo-Congolian mangrove and strand forest tree, Oxystigma mannii (Baill.) Harms. The structures of the new compounds were determined based on their 1D and 2D NMR, HRMS and FTIR. DP4+ probabilities were used to assign the configurations for compound 2. The two compounds were tested for their antimicrobial effects against Saccharomyces cerevisiae (BY4743), Escherichia coli (BW25113) and Bacillus subtilis (BY4743), but no inhibition was observed at the maximum concentrations tested (800 μM). ",

author = "Holly Siddique",

year = "2021",

month = mar,

day = "24",

doi = "10.1016/j.sciaf.2021.e00751",

language = "English",

volume = "12",

journal = "Scientific African ",

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T1 - Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

AU - Siddique, Holly

PY - 2021/3/24

Y1 - 2021/3/24

N2 - We describe two new terpenoids, 3′',5′'-dihydroxycinnamoyl-3β,28,30-dihydroxylup-20(29)-ene (1) and 6S,9S-dihydroxycasbe-3E,7E,11E-trien-5,10-dione (2) and ten known asperglaucide, aridanin, isoscopoletin, maslinic acid, ursolic acid, oleanolic acid, lupeol, sitosterol, stigmasterol and stigmasterol-glucoside from a West African, Guineo-Congolian mangrove and strand forest tree, Oxystigma mannii (Baill.) Harms. The structures of the new compounds were determined based on their 1D and 2D NMR, HRMS and FTIR. DP4+ probabilities were used to assign the configurations for compound 2. The two compounds were tested for their antimicrobial effects against Saccharomyces cerevisiae (BY4743), Escherichia coli (BW25113) and Bacillus subtilis (BY4743), but no inhibition was observed at the maximum concentrations tested (800 μM).

AB - We describe two new terpenoids, 3′',5′'-dihydroxycinnamoyl-3β,28,30-dihydroxylup-20(29)-ene (1) and 6S,9S-dihydroxycasbe-3E,7E,11E-trien-5,10-dione (2) and ten known asperglaucide, aridanin, isoscopoletin, maslinic acid, ursolic acid, oleanolic acid, lupeol, sitosterol, stigmasterol and stigmasterol-glucoside from a West African, Guineo-Congolian mangrove and strand forest tree, Oxystigma mannii (Baill.) Harms. The structures of the new compounds were determined based on their 1D and 2D NMR, HRMS and FTIR. DP4+ probabilities were used to assign the configurations for compound 2. The two compounds were tested for their antimicrobial effects against Saccharomyces cerevisiae (BY4743), Escherichia coli (BW25113) and Bacillus subtilis (BY4743), but no inhibition was observed at the maximum concentrations tested (800 μM).

U2 - 10.1016/j.sciaf.2021.e00751

DO - 10.1016/j.sciaf.2021.e00751

M3 - Article

VL - 12

JO - Scientific African

JF - Scientific African

ER -

Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

Abstract

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