The combination of dissimilar alleles of the A-alpha and A-beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus

U. Kues, W.V.J. Richardson, A.M. Tymon, Euphemia Mutasa-Gottgens, B. Gottgens, S. Gaubatz, A. Gregoriades, L.A. Casselton

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

The A mating-type factor is one of two gene complexes that allows mating cells of the mushroom Coprinus cinereus to recognize self from nonself and to regulate a pathway of sexual development that leads to meiosis and sporulation. We have identified seven A genes separated into two subcomplexes corresponding to the classical A-alpha and A-beta loci. Four genes, one-alpha and three-beta, all coding for proteins with a homeo domain-related motif, determine A-factor specificity; their allelic forms are so different in sequence that they do not cross-hybridize. It requires only one of these four genes to be heteroallelic in a cell to trigger A-regulated sexual development, and it is the different combinations of their alleles that generate the multiple A factors found in nature. The other three genes cause no change in cell morphology and may regulate the activity of the four specificity genes

Original languageEnglish
Pages (from-to)568-577
Number of pages10
JournalGenes and Development
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 1992

Keywords

  • HOMEO DOMAIN MOTIFS
  • SEXUAL DEVELOPMENT
  • RIBONUCLEIC-ACID
  • HOMEODOMAIN
  • MATING TYPE
  • MAYDIS
  • TRANSFORMATION
  • DNA
  • COPRINUS
  • EXPRESSION
  • SEXUAL COMPATIBILITY
  • YEAST
  • CLONING

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