Abstract
The A mating-type factor is one of two gene complexes that allows mating cells of the mushroom Coprinus cinereus to recognize self from nonself and to regulate a pathway of sexual development that leads to meiosis and sporulation. We have identified seven A genes separated into two subcomplexes corresponding to the classical A-alpha and A-beta loci. Four genes, one-alpha and three-beta, all coding for proteins with a homeo domain-related motif, determine A-factor specificity; their allelic forms are so different in sequence that they do not cross-hybridize. It requires only one of these four genes to be heteroallelic in a cell to trigger A-regulated sexual development, and it is the different combinations of their alleles that generate the multiple A factors found in nature. The other three genes cause no change in cell morphology and may regulate the activity of the four specificity genes
Original language | English |
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Pages (from-to) | 568-577 |
Number of pages | 10 |
Journal | Genes and Development |
Volume | 6 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 1992 |
Keywords
- HOMEO DOMAIN MOTIFS
- SEXUAL DEVELOPMENT
- RIBONUCLEIC-ACID
- HOMEODOMAIN
- MATING TYPE
- MAYDIS
- TRANSFORMATION
- DNA
- COPRINUS
- EXPRESSION
- SEXUAL COMPATIBILITY
- YEAST
- CLONING