The e-psychonaut drugs’ psychopharmacology

Fabrizio Schifano, Stephania Chiappini, John Martin Corkery, Norbert Scherbaum, Amira Guirguis

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
30 Downloads (Pure)


The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCP/ketamine-like compounds, prescribed medicinal compounds and popular psychotropic herbs/plants) discussed by Internet-based enthusiasts of new/novel psychoactive substances (NPS), ‘e-psychonauts’. Currently ongoing related in silico studies, followed by further in vitro and in vivo/preclinical studies, will hopefully provide important findings in terms of which molecules within each given NPS class may present with higher levels of receptor affinities, and hence clinical potency. Understanding the pharmacological characteristics/potency of those novel recreational molecules will hopefully help in predicting related NPS diffusion, morbidity and possible lethality data.
Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalCurrent Opinion in Pharmacology
Early online date25 Mar 2021
Publication statusPublished - 1 Apr 2021


  • e-psychonauts
  • psychopharmacology
  • addiction
  • new psychoactive substances
  • novel psychoactive substances
  • NPS
  • drug abuse
  • Drug abuse
  • Novel psychoactive substances
  • Addiction
  • Psychopharmacology
  • New psychoactive substances


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