The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Hyun Kuk Kim; Udaya S. Tantry; Sidney C. Smith; Myung Ho Jeong; Seung Jung Park; Moo Hyun Kim; Do Sun Lim; Eun Seok Shin; Duk Woo Park; Yong Huo; Shao Liang Chen; Zheng Bo; Shinya Goto; Takeshi Kimura; Satoshi Yasuda; Wen Jone Chen; Mark Chan; Daniel Aradi; Tobias Geisler; Diana A. Gorog; Dirk Sibbing; Gregory Y.H. Lip; Dominick J. Angiolillo; Paul A. Gurbel; Young Hoon Jeong

doi:10.1055/s-0040-1718729

The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Hyun Kuk Kim, Udaya S. Tantry, Sidney C. Smith, Myung Ho Jeong, Seung Jung Park, Moo Hyun Kim, Do Sun Lim, Eun Seok Shin, Duk Woo Park, Yong Huo, Shao Liang Chen, Zheng Bo, Shinya Goto, Takeshi Kimura, Satoshi Yasuda, Wen Jone Chen, Mark Chan, Daniel Aradi, Tobias Geisler, Diana A. GorogDirk Sibbing, Gregory Y.H. Lip, Dominick J. Angiolillo, Paul A. Gurbel, Young Hoon Jeong

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Abstract

East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

Original language	English
Pages (from-to)	11
Number of pages	422
Journal	Thrombosis and haemostasis
Volume	121
Issue number	04
Early online date	10 Nov 2020
DOIs	https://doi.org/10.1055/s-0040-1718729
Publication status	E-pub ahead of print - 10 Nov 2020

Keywords

antiplatelet therapy
bleeding risk
direct oral anticoagulants
ischemic risk
race

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© 2020. Thieme. All rights reserved. Georg Thieme Verlag KG. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1055/s-0040-1718729.
Accepted author manuscript, 1.71 MBLicence: Unspecified

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Kim, H. K., Tantry, U. S., Smith, S. C., Jeong, M. H., Park, S. J., Kim, M. H., Lim, D. S., Shin, E. S., Park, D. W., Huo, Y., Chen, S. L., Bo, Z., Goto, S., Kimura, T., Yasuda, S., Chen, W. J., Chan, M., Aradi, D., Geisler, T., ... Jeong, Y. H. (2020). The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease. Thrombosis and haemostasis, 121(04), 11. Advance online publication. https://doi.org/10.1055/s-0040-1718729

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title = "The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease",

abstract = "East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.",

keywords = "antiplatelet therapy, bleeding risk, direct oral anticoagulants, ischemic risk, race",

author = "Kim, {Hyun Kuk} and Tantry, {Udaya S.} and Smith, {Sidney C.} and Jeong, {Myung Ho} and Park, {Seung Jung} and Kim, {Moo Hyun} and Lim, {Do Sun} and Shin, {Eun Seok} and Park, {Duk Woo} and Yong Huo and Chen, {Shao Liang} and Zheng Bo and Shinya Goto and Takeshi Kimura and Satoshi Yasuda and Chen, {Wen Jone} and Mark Chan and Daniel Aradi and Tobias Geisler and Gorog, {Diana A.} and Dirk Sibbing and Lip, {Gregory Y.H.} and Angiolillo, {Dominick J.} and Gurbel, {Paul A.} and Jeong, {Young Hoon}",

note = "{\textcopyright} 2020. Thieme. All rights reserved. Georg Thieme Verlag KG. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1055/s-0040-1718729. ",

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Kim, HK, Tantry, US, Smith, SC, Jeong, MH, Park, SJ, Kim, MH, Lim, DS, Shin, ES, Park, DW, Huo, Y, Chen, SL, Bo, Z, Goto, S, Kimura, T, Yasuda, S, Chen, WJ, Chan, M, Aradi, D, Geisler, T, Gorog, DA, Sibbing, D, Lip, GYH, Angiolillo, DJ, Gurbel, PA & Jeong, YH 2020, 'The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease', Thrombosis and haemostasis, vol. 121, no. 04, pp. 11. https://doi.org/10.1055/s-0040-1718729

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T2 - An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

AU - Kim, Hyun Kuk

AU - Tantry, Udaya S.

AU - Smith, Sidney C.

AU - Jeong, Myung Ho

AU - Park, Seung Jung

AU - Kim, Moo Hyun

AU - Lim, Do Sun

AU - Shin, Eun Seok

AU - Park, Duk Woo

AU - Huo, Yong

AU - Chen, Shao Liang

AU - Bo, Zheng

AU - Goto, Shinya

AU - Kimura, Takeshi

AU - Yasuda, Satoshi

AU - Chen, Wen Jone

AU - Chan, Mark

AU - Aradi, Daniel

AU - Geisler, Tobias

AU - Gorog, Diana A.

AU - Sibbing, Dirk

AU - Lip, Gregory Y.H.

AU - Angiolillo, Dominick J.

AU - Gurbel, Paul A.

AU - Jeong, Young Hoon

N1 - © 2020. Thieme. All rights reserved. Georg Thieme Verlag KG. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1055/s-0040-1718729.

PY - 2020/11/10

Y1 - 2020/11/10

N2 - East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

AB - East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

KW - antiplatelet therapy

KW - bleeding risk

KW - direct oral anticoagulants

KW - ischemic risk

KW - race

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M3 - Review article

C2 - 33171520

AN - SCOPUS:85096095586

SN - 0340-6245

VL - 121

SP - 11

JO - Thrombosis and haemostasis

JF - Thrombosis and haemostasis

IS - 04

ER -

The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Abstract

Keywords

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