TY - JOUR
T1 - The effect of phenyl substituents on C NMR shifts and metal ions binding to 4-Phenyl-2,4-dioxobutanoic acid derivatives
AU - Verbić, T.Z.
AU - Juranić, I.O.
AU - Drakulić, B.J.
AU - Zloh, Mire
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alky1 substituted compounds, was observed. This observation might have pharmacological implications
AB - Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alky1 substituted compounds, was observed. This observation might have pharmacological implications
UR - http://www.scopus.com/inward/record.url?scp=70349624346&partnerID=8YFLogxK
U2 - 10.2174/157017808786857589
DO - 10.2174/157017808786857589
M3 - Article
AN - SCOPUS:70349624346
SN - 1570-1786
VL - 5
SP - 692
EP - 699
JO - Letters in Organic Chemistry
JF - Letters in Organic Chemistry
IS - 8
ER -