TY - JOUR
T1 - The Effect of Polymorphism A/T 251 of the IL-8 Gene on Breast Cancer: A Systematic Review and Meta-Analysis
AU - Salari, Nader
AU - Kazeminia, Mohsen
AU - Hosseinian Far, Amin
AU - Mansouri, Kamran
AU - Mohammadi, Masoud
AU - Alazmani Noodeh, Farshid
N1 - M1 - 70
PY - 2021/7/26
Y1 - 2021/7/26
N2 - PurposeBreast cancer is the most common cancer in women. In recent research works, the role of cytokines in development of cancer has attracted attention. Therefore, this paper intends to comprehensively assess the association between breast cancer and polymorphism A/T 251 from the IL-8 gene using meta-analysis.MethodsIn this study, to find articles published electronically between 2004 and 2020, national and international databases of SID, MagIran, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS).ResultsThe odds ratio of AA genotype in patients with breast cancer based was obtained as 1.42 (1.11–1.82: 95% confidence interval), which shows the increasing effect of AA genotype by 0.42, the odds ratio of the AT genotype in patients with breast cancer based on a meta-analysis of studies was obtained as 1.01 (0.84–1.22: 95% confidence interval), which demonstrates the increasing effect of the AT genotype by 0.01, and the odds ratio of the TT genotype in patients with breast cancer was similarly obtained and was 0.95 (1.08–0.24: 95% confidence limit), which shows the decreasing effect of TT genotype by 0.05.ConclusionAccording to this meta-analysis, allele A has a significant relationship with breast cancer, which can be used as a predictor of the course of the disease and the clinical outcome of breast cancer. Identifying polymorphism A/T 251 from the IL-8 gene, as a genetic marker and predictor, can also be effective in treating breast cancer.
AB - PurposeBreast cancer is the most common cancer in women. In recent research works, the role of cytokines in development of cancer has attracted attention. Therefore, this paper intends to comprehensively assess the association between breast cancer and polymorphism A/T 251 from the IL-8 gene using meta-analysis.MethodsIn this study, to find articles published electronically between 2004 and 2020, national and international databases of SID, MagIran, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS).ResultsThe odds ratio of AA genotype in patients with breast cancer based was obtained as 1.42 (1.11–1.82: 95% confidence interval), which shows the increasing effect of AA genotype by 0.42, the odds ratio of the AT genotype in patients with breast cancer based on a meta-analysis of studies was obtained as 1.01 (0.84–1.22: 95% confidence interval), which demonstrates the increasing effect of the AT genotype by 0.01, and the odds ratio of the TT genotype in patients with breast cancer was similarly obtained and was 0.95 (1.08–0.24: 95% confidence limit), which shows the decreasing effect of TT genotype by 0.05.ConclusionAccording to this meta-analysis, allele A has a significant relationship with breast cancer, which can be used as a predictor of the course of the disease and the clinical outcome of breast cancer. Identifying polymorphism A/T 251 from the IL-8 gene, as a genetic marker and predictor, can also be effective in treating breast cancer.
U2 - 10.1007/s40944-021-00571-3
DO - 10.1007/s40944-021-00571-3
M3 - Article
SN - 2363-8397
VL - 19
JO - Indian Journal of Gynecologic Oncology
JF - Indian Journal of Gynecologic Oncology
ER -