The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus

Christopher Keating; Lindy Holden-Dye; Michael C. Thorndyke; R.G. Williams; A. Mallett; Robert J. Walker

doi:10.1017/S0031182000066026

The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus

Christopher Keating
, Lindy Holden-Dye
, Michael C. Thorndyke
, R.G. Williams
, A. Mallett
, Robert J. Walker

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode

Original language	English
Pages (from-to)	515-521
Journal	Parasitology
Volume	111
Issue number	4
DOIs	https://doi.org/10.1017/S0031182000066026
Publication status	Published - Nov 1995

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title = "The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus",

abstract = "Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode",

author = "Christopher Keating and Lindy Holden-Dye and Thorndyke, \{Michael C.\} and R.G. Williams and A. Mallett and Walker, \{Robert J.\}",

year = "1995",

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doi = "10.1017/S0031182000066026",

language = "English",

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TY - JOUR

T1 - The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus

AU - Keating, Christopher

AU - Holden-Dye, Lindy

AU - Thorndyke, Michael C.

AU - Williams, R.G.

AU - Mallett, A.

AU - Walker, Robert J.

PY - 1995/11

Y1 - 1995/11

N2 - Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode

AB - Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode

U2 - 10.1017/S0031182000066026

DO - 10.1017/S0031182000066026

M3 - Article

SN - 0031-1820

VL - 111

SP - 515

EP - 521

JO - Parasitology

JF - Parasitology

IS - 4

ER -

The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus

Abstract

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