TY - JOUR
T1 - The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics
AU - Gerhard, U.
AU - Searle, M.S.
AU - Williams, D.H.
N1 - Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The adverse cost in free energy of restricting an internal bond rotation in the binding of the peptide ligands N-succinyl-D-alanine and N-fumaryl-D-alanine to the antibiotic Ristocetin A, has been estimated to be 3.7 ± 0.9 kJ mol per rotor by comparison of the difference in free energies of binding measured by UV spectrometry.
AB - The adverse cost in free energy of restricting an internal bond rotation in the binding of the peptide ligands N-succinyl-D-alanine and N-fumaryl-D-alanine to the antibiotic Ristocetin A, has been estimated to be 3.7 ± 0.9 kJ mol per rotor by comparison of the difference in free energies of binding measured by UV spectrometry.
UR - http://www.scopus.com/inward/record.url?scp=0027241298&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)80670-8
DO - 10.1016/S0960-894X(00)80670-8
M3 - Article
AN - SCOPUS:0027241298
SN - 0960-894X
VL - 3
SP - 803
EP - 808
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 5
ER -