The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep

S.A.J. Strain; S.C. Bishop; N.G. Henderson; A. Kerr; Quintin McKellar; S. Mitchell; M.J. Stear

doi:10.1017/S0031182002001531

The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep

S.A.J. Strain, S.C. Bishop, N.G. Henderson, A. Kerr, Quintin McKellar, S. Mitchell, M.J. Stear

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this research,,vas to determine if these results could be confirmed in naturally infected sheep and to explore the hypothesis that plasma IgA activity could help to identify resistant lambs with shorter adult nematodes. Plasma IgA activity was skewed with most animals having relatively low levels of IgA activity. Plasma IgA activity, was repeatable and highly heritable. Animals with increased IgA activity had lower egg counts and shorter adult female T. circumcincta. Therefore, under conditions of natural parasite challenge, plasma IgA activity, may help to identify lambs resistant to T. circumcincta.

Original language	English
Pages (from-to)	545-552
Number of pages	8
Journal	Parasitology
Volume	124
Issue number	05
DOIs	https://doi.org/10.1017/S0031182002001531
Publication status	Published - May 2002

Keywords

sheep
nematoda
Teladorsagia circumcincta
IgA
marker
indicator trait

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title = "The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep",

abstract = "Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this research,,vas to determine if these results could be confirmed in naturally infected sheep and to explore the hypothesis that plasma IgA activity could help to identify resistant lambs with shorter adult nematodes. Plasma IgA activity was skewed with most animals having relatively low levels of IgA activity. Plasma IgA activity, was repeatable and highly heritable. Animals with increased IgA activity had lower egg counts and shorter adult female T. circumcincta. Therefore, under conditions of natural parasite challenge, plasma IgA activity, may help to identify lambs resistant to T. circumcincta.",

keywords = "sheep, nematoda, Teladorsagia circumcincta, IgA, marker, indicator trait ",

author = "S.A.J. Strain and S.C. Bishop and N.G. Henderson and A. Kerr and Quintin McKellar and S. Mitchell and M.J. Stear",

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T1 - The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep

AU - Strain, S.A.J.

AU - Bishop, S.C.

AU - Henderson, N.G.

AU - Kerr, A.

AU - McKellar, Quintin

AU - Mitchell, S.

AU - Stear, M.J.

PY - 2002/5

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N2 - Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this research,,vas to determine if these results could be confirmed in naturally infected sheep and to explore the hypothesis that plasma IgA activity could help to identify resistant lambs with shorter adult nematodes. Plasma IgA activity was skewed with most animals having relatively low levels of IgA activity. Plasma IgA activity, was repeatable and highly heritable. Animals with increased IgA activity had lower egg counts and shorter adult female T. circumcincta. Therefore, under conditions of natural parasite challenge, plasma IgA activity, may help to identify lambs resistant to T. circumcincta.

AB - Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this research,,vas to determine if these results could be confirmed in naturally infected sheep and to explore the hypothesis that plasma IgA activity could help to identify resistant lambs with shorter adult nematodes. Plasma IgA activity was skewed with most animals having relatively low levels of IgA activity. Plasma IgA activity, was repeatable and highly heritable. Animals with increased IgA activity had lower egg counts and shorter adult female T. circumcincta. Therefore, under conditions of natural parasite challenge, plasma IgA activity, may help to identify lambs resistant to T. circumcincta.

KW - sheep

KW - nematoda

KW - Teladorsagia circumcincta

KW - IgA

KW - marker

KW - indicator trait

U2 - 10.1017/S0031182002001531

DO - 10.1017/S0031182002001531

M3 - Article

SN - 1469-8161

VL - 124

SP - 545

EP - 552

JO - Parasitology

JF - Parasitology

IS - 05

ER -

The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep

Abstract

Keywords

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