TY - JOUR
T1 - The molecular mystery of neuronal migration
T2 - FAK and Cdk5
AU - Nikolic, M.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2004
Y1 - 2004
N2 - The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.
AB - The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.
UR - http://www.scopus.com/inward/record.url?scp=0347285297&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2003.10.010
DO - 10.1016/j.tcb.2003.10.010
M3 - Article
AN - SCOPUS:0347285297
SN - 0962-8924
VL - 14
SP - 1
EP - 5
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -