The Rtc RNA end healing and sealing system

Danai Athina Irakleidi; Harry Beaven; Martin Buck; Ioly Kotta-Loizou

doi:10.1007/978-3-030-76571-2_3

The Rtc RNA end healing and sealing system

Danai Athina Irakleidi, Harry Beaven, Martin Buck, Ioly Kotta-Loizou

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

RNA occupies a central position in living systems, as an intermediate in information flow from DNA to proteins, as structural element of the ribosomes and as a regulator of gene expression at transcriptional and translational levels. Its formation and maturation is controlled through numerous enzymatic activities. Rather less well understood are the systems that act to restore the integrity of RNA. Here we describe one such system, focusing on the bacterial Rtc RNA end modification and ligation mediated respectively by the RtcA and RtcB enzymes, whose expression relies on an enhancer binding transcription control protein RtcR.

Original language	English
Title of host publication	RNA Damage and Repair
Publisher	Springer Nature Link
Pages	53-72
Number of pages	20
ISBN (Electronic)	9783030765712
ISBN (Print)	9783030765705
DOIs	https://doi.org/10.1007/978-3-030-76571-2_3
Publication status	Published - 4 Jul 2021
Externally published	Yes

Keywords

CARF domain
CRISPR-Cas systems
Ribotoxins
RNA damage
RNA end sealing
RNA repair
RtcA RNA cyclase
RtcB RNA ligase
RtcR transcriptional activator

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10.1007/978-3-030-76571-2_3

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AU - Irakleidi, Danai Athina

AU - Beaven, Harry

AU - Buck, Martin

AU - Kotta-Loizou, Ioly

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Y1 - 2021/7/4

N2 - RNA occupies a central position in living systems, as an intermediate in information flow from DNA to proteins, as structural element of the ribosomes and as a regulator of gene expression at transcriptional and translational levels. Its formation and maturation is controlled through numerous enzymatic activities. Rather less well understood are the systems that act to restore the integrity of RNA. Here we describe one such system, focusing on the bacterial Rtc RNA end modification and ligation mediated respectively by the RtcA and RtcB enzymes, whose expression relies on an enhancer binding transcription control protein RtcR.

AB - RNA occupies a central position in living systems, as an intermediate in information flow from DNA to proteins, as structural element of the ribosomes and as a regulator of gene expression at transcriptional and translational levels. Its formation and maturation is controlled through numerous enzymatic activities. Rather less well understood are the systems that act to restore the integrity of RNA. Here we describe one such system, focusing on the bacterial Rtc RNA end modification and ligation mediated respectively by the RtcA and RtcB enzymes, whose expression relies on an enhancer binding transcription control protein RtcR.

KW - CARF domain

KW - CRISPR-Cas systems

KW - Ribotoxins

KW - RNA damage

KW - RNA end sealing

KW - RNA repair

KW - RtcA RNA cyclase

KW - RtcB RNA ligase

KW - RtcR transcriptional activator

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SN - 9783030765705

SP - 53

EP - 72

BT - RNA Damage and Repair

PB - Springer Nature Link

ER -

The Rtc RNA end healing and sealing system

Abstract

Keywords

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