Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model

Simon D. Baines; Katie Saxton; Jane Freeman; Mark H. Wilcox

doi:10.1093/jac/dkl364

Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model

Simon D. Baines, Katie Saxton, Jane Freeman, Mark H. Wilcox

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.

Original language	English
Pages (from-to)	1062-5
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	58
Issue number	5
DOIs	https://doi.org/10.1093/jac/dkl364
Publication status	Published - 2006

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title = "Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model",

abstract = "Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.",

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AU - Saxton, Katie

AU - Freeman, Jane

AU - Wilcox, Mark H.

PY - 2006

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N2 - Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.

AB - Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.

U2 - 10.1093/jac/dkl364

DO - 10.1093/jac/dkl364

M3 - Article

C2 - 17030519

SN - 0305-7453

VL - 58

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 5

ER -

Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model

Abstract

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