Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)

Mark Dixon, Jason P Appleton, Polly Scutt, Lisa J Woodhouse, Lee J Haywood, Diane Havard, Julia Williams, Aloysius Niroshan Siriwardena, Philip M Bath

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Ambulances offer the first opportunity to evaluate hyperacute stroke treatments. In this study, we investigated the conduct of a hyperacute stroke study in the ambulance-based setting with a particular focus on timings and logistics of trial delivery. Design: Multicentre prospective, single-blind, parallel group randomised controlled trial. Setting: Eight National Health Service ambulance services in England and Wales; 54 acute stroke centres. Participants: Paramedics enrolled 1149 patients assessed as likely to have a stroke, with Face, Arm, Speech and Time score (2 or 3), within 4 hours of symptom onset and systolic blood pressure >120 mm Hg. Interventions: Paramedics administered randomly assigned active transdermal glyceryl trinitrate or sham. Primary and secondary outcomes: Modified Rankin scale at day 90. This paper focuses on response time intervals, distances travelled and baseline characteristics of patients, compared between ambulance services. Results: Paramedics enrolled 1149 patients between September 2015 and May 2018. Final diagnosis: intracerebral haemorrhage 13%, ischaemic stroke 52%, transient ischaemic attack 9% and mimic 26%. Timings (min) were (median (25–75 centile)): onset to emergency call 19 (5–64); onset to randomisation 71 (45–116); total time at scene 33 (26–46); depart scene to hospital 15 (10–23); randomisation to hospital 24 (16–34) and onset to hospital 97 (71–141). Ambulances travelled (km) 10 (4–19) from scene to hospital. Timings and distances differed between ambulance service, for example, onset to randomisation (fastest 53 min, slowest 77 min; p
Original languageEnglish
Article numbere060211
Number of pages8
JournalBMJ Open
Volume12
Issue number11
DOIs
Publication statusPublished - 21 Nov 2022

Keywords

  • Neurology
  • 1506
  • 1713
  • stroke
  • accident & emergency medicine
  • stroke medicine

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