Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

Simon D. Baines; Jane Freeman; M. H. Wilcox

doi:10.1128/AAC.01085-08

Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

Simon D. Baines, Jane Freeman, M. H. Wilcox

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38 Citations (Scopus)

Abstract

The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.

Original language	English
Pages (from-to)	2202-4
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01085-08
Publication status	Published - 2009

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title = "Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection",

abstract = "The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.",

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AB - The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

Abstract

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