Towards host-directed therapies for tuberculosis

Alimuddin Zumla; Markus Maeurer; Jeremiah Chakaya; Michael Hoelscher; Francine Ntoumi; Roxana Rustomjee; Cristina Vilaplana; Dorothy Yeboah-Manu; Voahangy Rasolof; Paula Munderi; Nalini Singh; Eleni Aklillu; Nesri Padayatchi; Eusebio Macete; Nathan Kapata; Modest Mulenga; Gibson Kibiki; Sayoki Mfinanga; Thomas Nyirenda; Leonard Maboko; Alberto Garcia-Basteiro; Niaina Rakotosamimanana; Matthew Bates; Peter Mwaba; Klaus Reither; Sebastien Gagneux; Sarah Edwards; Elirehema Mfinanga; Salim Abdulla; Pere-Joan Cardona; James B W Russell; Vanya Gant; Mahdad Noursadeghi; Paul Elkington; Maryline Bonnet; Clara Menendez; Tandakha N Dieye; Bassirou Diarra; Almoustapha Maiga; Abraham Aseffa; Shreemanta Parida; Christian Wejse; Eskild Petersen; Pontiano Kaleebu; Matt Oliver; Gill Craig; Tumena Corrah; Leopold Tientcheu; Martin Antonio; Martin Rao; Host-Directed Therapies Network

doi:10.1038/nrd4696

Towards host-directed therapies for tuberculosis

Alimuddin Zumla, Markus Maeurer, Jeremiah Chakaya, Michael Hoelscher, Francine Ntoumi, Roxana Rustomjee, Cristina Vilaplana, Dorothy Yeboah-Manu, Voahangy Rasolof, Paula Munderi, Nalini Singh, Eleni Aklillu, Nesri Padayatchi, Eusebio Macete, Nathan Kapata, Modest Mulenga, Gibson Kibiki, Sayoki Mfinanga, Thomas Nyirenda, Leonard MabokoAlberto Garcia-Basteiro, Niaina Rakotosamimanana, Matthew Bates, Peter Mwaba, Klaus Reither, Sebastien Gagneux, Sarah Edwards, Elirehema Mfinanga, Salim Abdulla, Pere-Joan Cardona, James B W Russell, Vanya Gant, Mahdad Noursadeghi, Paul Elkington, Maryline Bonnet, Clara Menendez, Tandakha N Dieye, Bassirou Diarra, Almoustapha Maiga, Abraham Aseffa, Shreemanta Parida, Christian Wejse, Eskild Petersen, Pontiano Kaleebu, Matt Oliver, Gill Craig, Tumena Corrah, Leopold Tientcheu, Martin Antonio, Martin Rao, Host-Directed Therapies Network

Research output: Contribution to journal › Comment/debate › peer-review

80 Citations (Scopus)

Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

Original language	English
Pages (from-to)	511-2
Number of pages	2
Journal	Nature reviews. Drug discovery
Volume	14
Issue number	8
DOIs	https://doi.org/10.1038/nrd4696
Publication status	Published - 17 Jul 2015

Keywords

Antitubercular Agents
Drug Design
Drug Therapy, Combination
Humans
Molecular Targeted Therapy
Mycobacterium tuberculosis
Tuberculosis
Journal Article

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10.1038/nrd4696

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Zumla, A., Maeurer, M., Chakaya, J., Hoelscher, M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., Rasolof, V., Munderi, P., Singh, N., Aklillu, E., Padayatchi, N., Macete, E., Kapata, N., Mulenga, M., Kibiki, G., Mfinanga, S., Nyirenda, T., ... Host-Directed Therapies Network (2015). Towards host-directed therapies for tuberculosis. Nature reviews. Drug discovery, 14(8), 511-2. https://doi.org/10.1038/nrd4696

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title = "Towards host-directed therapies for tuberculosis",

abstract = "The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.",

keywords = "Antitubercular Agents, Drug Design, Drug Therapy, Combination, Humans, Molecular Targeted Therapy, Mycobacterium tuberculosis, Tuberculosis, Journal Article",

author = "Alimuddin Zumla and Markus Maeurer and Jeremiah Chakaya and Michael Hoelscher and Francine Ntoumi and Roxana Rustomjee and Cristina Vilaplana and Dorothy Yeboah-Manu and Voahangy Rasolof and Paula Munderi and Nalini Singh and Eleni Aklillu and Nesri Padayatchi and Eusebio Macete and Nathan Kapata and Modest Mulenga and Gibson Kibiki and Sayoki Mfinanga and Thomas Nyirenda and Leonard Maboko and Alberto Garcia-Basteiro and Niaina Rakotosamimanana and Matthew Bates and Peter Mwaba and Klaus Reither and Sebastien Gagneux and Sarah Edwards and Elirehema Mfinanga and Salim Abdulla and Pere-Joan Cardona and Russell, {James B W} and Vanya Gant and Mahdad Noursadeghi and Paul Elkington and Maryline Bonnet and Clara Menendez and Dieye, {Tandakha N} and Bassirou Diarra and Almoustapha Maiga and Abraham Aseffa and Shreemanta Parida and Christian Wejse and Eskild Petersen and Pontiano Kaleebu and Matt Oliver and Gill Craig and Tumena Corrah and Leopold Tientcheu and Martin Antonio and Martin Rao and {Host-Directed Therapies Network}",

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doi = "10.1038/nrd4696",

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Zumla, A, Maeurer, M, Chakaya, J, Hoelscher, M, Ntoumi, F, Rustomjee, R, Vilaplana, C, Yeboah-Manu, D, Rasolof, V, Munderi, P, Singh, N, Aklillu, E, Padayatchi, N, Macete, E, Kapata, N, Mulenga, M, Kibiki, G, Mfinanga, S, Nyirenda, T, Maboko, L, Garcia-Basteiro, A, Rakotosamimanana, N, Bates, M, Mwaba, P, Reither, K, Gagneux, S, Edwards, S, Mfinanga, E, Abdulla, S, Cardona, P-J, Russell, JBW, Gant, V, Noursadeghi, M, Elkington, P, Bonnet, M, Menendez, C, Dieye, TN, Diarra, B, Maiga, A, Aseffa, A, Parida, S, Wejse, C, Petersen, E, Kaleebu, P, Oliver, M, Craig, G, Corrah, T, Tientcheu, L, Antonio, M, Rao, M & Host-Directed Therapies Network 2015, 'Towards host-directed therapies for tuberculosis', Nature reviews. Drug discovery, vol. 14, no. 8, pp. 511-2. https://doi.org/10.1038/nrd4696

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T1 - Towards host-directed therapies for tuberculosis

AU - Zumla, Alimuddin

AU - Maeurer, Markus

AU - Chakaya, Jeremiah

AU - Hoelscher, Michael

AU - Ntoumi, Francine

AU - Rustomjee, Roxana

AU - Vilaplana, Cristina

AU - Yeboah-Manu, Dorothy

AU - Rasolof, Voahangy

AU - Munderi, Paula

AU - Singh, Nalini

AU - Aklillu, Eleni

AU - Padayatchi, Nesri

AU - Macete, Eusebio

AU - Kapata, Nathan

AU - Mulenga, Modest

AU - Kibiki, Gibson

AU - Mfinanga, Sayoki

AU - Nyirenda, Thomas

AU - Maboko, Leonard

AU - Garcia-Basteiro, Alberto

AU - Rakotosamimanana, Niaina

AU - Bates, Matthew

AU - Mwaba, Peter

AU - Reither, Klaus

AU - Gagneux, Sebastien

AU - Edwards, Sarah

AU - Mfinanga, Elirehema

AU - Abdulla, Salim

AU - Cardona, Pere-Joan

AU - Russell, James B W

AU - Gant, Vanya

AU - Noursadeghi, Mahdad

AU - Elkington, Paul

AU - Bonnet, Maryline

AU - Menendez, Clara

AU - Dieye, Tandakha N

AU - Diarra, Bassirou

AU - Maiga, Almoustapha

AU - Aseffa, Abraham

AU - Parida, Shreemanta

AU - Wejse, Christian

AU - Petersen, Eskild

AU - Kaleebu, Pontiano

AU - Oliver, Matt

AU - Craig, Gill

AU - Corrah, Tumena

AU - Tientcheu, Leopold

AU - Antonio, Martin

AU - Rao, Martin

AU - Host-Directed Therapies Network

PY - 2015/7/17

Y1 - 2015/7/17

N2 - The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

AB - The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

KW - Antitubercular Agents

KW - Drug Design

KW - Drug Therapy, Combination

KW - Humans

KW - Molecular Targeted Therapy

KW - Mycobacterium tuberculosis

KW - Tuberculosis

KW - Journal Article

U2 - 10.1038/nrd4696

DO - 10.1038/nrd4696

M3 - Comment/debate

C2 - 26184493

SN - 1474-1776

VL - 14

SP - 511

EP - 512

JO - Nature reviews. Drug discovery

JF - Nature reviews. Drug discovery

IS - 8

ER -

Towards host-directed therapies for tuberculosis

Abstract

Keywords

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