Transglutaminase Crosslinked Collagen Biomaterial for Medical Implant Materials

M. Griffin (Inventor), Russell J. Collighan (Inventor), David Y.S. Chau (Inventor), E. Verderio Edwards (Inventor)

Research output: Patent


The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen biomaterial further comprises a cell adhesion factor, such as fibronectin. The invention further provides biomaterials obtainable by the methods of the invention, and medical implants and wound dressings comprising the same
Original languageEnglish
Patent numberWO2006027622
Publication statusPublished - 16 Mar 2006


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