TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia

E. Fonfria; C. Mattei; K. Hill; J.T. Brown; A.D. Randall; C.D. Benham; S.D. Skaper; C.A. Campbell; B. Crook; P.R. Murdoch; J.M. Wilson; F.P. Murio; D. Owen; P.L. Tilling; S. McNulty

doi:10.1080/10799890600637522

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia

E. Fonfria, C. Mattei, K. Hill, J.T. Brown, A.D. Randall, C.D. Benham, S.D. Skaper, C.A. Campbell, B. Crook, P.R. Murdoch, J.M. Wilson, F.P. Murio, D. Owen, P.L. Tilling, S. McNulty

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62 Citations (Scopus)

Abstract

We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tMCAO) stroke model. Microglial cells play a key role in pathology produced following ischemic injury in the CNS and possess TRPM2, which may contribute to stroke-related pathological responses. We show that TRPM2 mRNA is present in the human C13 microglial cell line and is reduced by antisense treatment. Activation of C13 cells by interleukin-1β leads to a fivefold increase of TRPM2 mRNA demonstrating transcriptional regulation

Original language	English
Pages (from-to)	179-198
Journal	Journal of Receptors and Signal Transduction Research
Volume	26
Issue number	3
DOIs	https://doi.org/10.1080/10799890600637522
Publication status	Published - 2006

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Fonfria, E., Mattei, C., Hill, K., Brown, J. T., Randall, A. D., Benham, C. D., Skaper, S. D., Campbell, C. A., Crook, B., Murdoch, P. R., Wilson, J. M., Murio, F. P., Owen, D., Tilling, P. L., & McNulty, S. (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia. Journal of Receptors and Signal Transduction Research, 26(3), 179-198. https://doi.org/10.1080/10799890600637522

@article{845ba2d2b8284ceb9b824f1ba3ae1ee7,

title = "TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia",

abstract = "We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tMCAO) stroke model. Microglial cells play a key role in pathology produced following ischemic injury in the CNS and possess TRPM2, which may contribute to stroke-related pathological responses. We show that TRPM2 mRNA is present in the human C13 microglial cell line and is reduced by antisense treatment. Activation of C13 cells by interleukin-1β leads to a fivefold increase of TRPM2 mRNA demonstrating transcriptional regulation",

author = "E. Fonfria and C. Mattei and K. Hill and J.T. Brown and A.D. Randall and C.D. Benham and S.D. Skaper and C.A. Campbell and B. Crook and P.R. Murdoch and J.M. Wilson and F.P. Murio and D. Owen and P.L. Tilling and S. McNulty",

note = "Original article can be found at: http://www.informaworld.com/smpp/title~content=t713597278 Copyright Informa / Taylor and Francis Group. DOI: 10.1080/10799890600637522 [Full text of this article is not available in the UHRA]",

year = "2006",

doi = "10.1080/10799890600637522",

language = "English",

volume = "26",

pages = "179--198",

journal = "Journal of Receptors and Signal Transduction Research",

issn = "1079-9893",

publisher = "Informa Healthcare",

number = "3",

}

Fonfria, E, Mattei, C, Hill, K, Brown, JT, Randall, AD, Benham, CD, Skaper, SD, Campbell, CA, Crook, B, Murdoch, PR, Wilson, JM, Murio, FP, Owen, D, Tilling, PL & McNulty, S 2006, 'TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia', Journal of Receptors and Signal Transduction Research, vol. 26, no. 3, pp. 179-198. https://doi.org/10.1080/10799890600637522

TY - JOUR

T1 - TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia

AU - Fonfria, E.

AU - Mattei, C.

AU - Hill, K.

AU - Brown, J.T.

AU - Randall, A.D.

AU - Benham, C.D.

AU - Skaper, S.D.

AU - Campbell, C.A.

AU - Crook, B.

AU - Murdoch, P.R.

AU - Wilson, J.M.

AU - Murio, F.P.

AU - Owen, D.

AU - Tilling, P.L.

AU - McNulty, S.

N1 - Original article can be found at: http://www.informaworld.com/smpp/title~content=t713597278 Copyright Informa / Taylor and Francis Group. DOI: 10.1080/10799890600637522 [Full text of this article is not available in the UHRA]

PY - 2006

Y1 - 2006

N2 - We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tMCAO) stroke model. Microglial cells play a key role in pathology produced following ischemic injury in the CNS and possess TRPM2, which may contribute to stroke-related pathological responses. We show that TRPM2 mRNA is present in the human C13 microglial cell line and is reduced by antisense treatment. Activation of C13 cells by interleukin-1β leads to a fivefold increase of TRPM2 mRNA demonstrating transcriptional regulation

AB - We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tMCAO) stroke model. Microglial cells play a key role in pathology produced following ischemic injury in the CNS and possess TRPM2, which may contribute to stroke-related pathological responses. We show that TRPM2 mRNA is present in the human C13 microglial cell line and is reduced by antisense treatment. Activation of C13 cells by interleukin-1β leads to a fivefold increase of TRPM2 mRNA demonstrating transcriptional regulation

U2 - 10.1080/10799890600637522

DO - 10.1080/10799890600637522

M3 - Article

SN - 1079-9893

VL - 26

SP - 179

EP - 198

JO - Journal of Receptors and Signal Transduction Research

JF - Journal of Receptors and Signal Transduction Research

IS - 3

ER -

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia

Abstract

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