Abstract
Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.
| Original language | English |
|---|---|
| Pages (from-to) | 751-8 |
| Number of pages | 8 |
| Journal | Journal of Infection in Developing Countries (JIDC) |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 10 Nov 2011 |
Keywords
- Cell Transformation, Viral
- Developing Countries
- Humans
- Neoplasms/epidemiology
- Retroviridae/pathogenicity
- Retroviridae Infections/complications