Tumorigenesis related to retroviral infections

Maria Braoudaki, Fotini Tzortzatou-Stathopoulou

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.

Original languageEnglish
Pages (from-to)751-8
Number of pages8
JournalJournal of Infection in Developing Countries (JIDC)
Issue number11
Publication statusPublished - 10 Nov 2011


  • Cell Transformation, Viral
  • Developing Countries
  • Humans
  • Neoplasms/epidemiology
  • Retroviridae/pathogenicity
  • Retroviridae Infections/complications


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