Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine: A Randomized Controlled Pilot Study

Leon Poltawski; Hazel Edwards; Amy Todd; Tim Watson; Andrew Lees; Cherry Ann James

doi:10.1002/mds.22316

Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine: A Randomized Controlled Pilot Study

Leon Poltawski, Hazel Edwards, Amy Todd, Tim Watson, Andrew Lees, Cherry Ann James

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area Judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but. more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study or the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted. (c) 2009 Movement Disorder Society

Original language	English
Pages (from-to)	115-118
Number of pages	4
Journal	Movement disorders
Volume	24
Issue number	1
DOIs	https://doi.org/10.1002/mds.22316
Publication status	Published - 15 Jan 2009

Keywords

Parkinson's disease
apomorphine
side effects
nodules
therapeutic ultrasound
clinical trial
PARKINSONS-DISEASE
SUBCUTANEOUS APOMORPHINE
DYSKINESIAS
THERAPY
PAIN

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title = "Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine: A Randomized Controlled Pilot Study",

abstract = "Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area Judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but. more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study or the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted. (c) 2009 Movement Disorder Society",

keywords = "Parkinson's disease, apomorphine, side effects, nodules, therapeutic ultrasound, clinical trial, PARKINSONS-DISEASE, SUBCUTANEOUS APOMORPHINE, DYSKINESIAS, THERAPY, PAIN",

author = "Leon Poltawski and Hazel Edwards and Amy Todd and Tim Watson and Andrew Lees and James, {Cherry Ann}",

note = "Original article can be found at: http://onlinelibrary.wiley.com/ Copyright Movement Disorders Society [Full text of this article is not available in the UHRA]",

year = "2009",

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AU - Poltawski, Leon

AU - Edwards, Hazel

AU - Todd, Amy

AU - Watson, Tim

AU - Lees, Andrew

AU - James, Cherry Ann

N1 - Original article can be found at: http://onlinelibrary.wiley.com/ Copyright Movement Disorders Society [Full text of this article is not available in the UHRA]

PY - 2009/1/15

Y1 - 2009/1/15

N2 - Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area Judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but. more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study or the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted. (c) 2009 Movement Disorder Society

AB - Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area Judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but. more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study or the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted. (c) 2009 Movement Disorder Society

KW - Parkinson's disease

KW - apomorphine

KW - side effects

KW - nodules

KW - therapeutic ultrasound

KW - clinical trial

KW - PARKINSONS-DISEASE

KW - SUBCUTANEOUS APOMORPHINE

KW - DYSKINESIAS

KW - THERAPY

KW - PAIN

U2 - 10.1002/mds.22316

DO - 10.1002/mds.22316

M3 - Article

SN - 0885-3185

VL - 24

SP - 115

EP - 118

JO - Movement disorders

JF - Movement disorders

IS - 1

ER -

Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine: A Randomized Controlled Pilot Study

Abstract

Keywords

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