TY - JOUR
T1 - Unravelling the impact of mycotoxins on gut health: implications for inflammatory bowel disease
AU - Gasperini, Alessandra Marcon
AU - Faccenda, Danilo
AU - Garcia-Cela, Esther
N1 - © 2025 The Author(s). Published by Elsevier Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution - Non-Commercial 4.0 International License (CC BY-NC), https://creativecommons.org/licenses/by-nc/4.0/
PY - 2025/5/22
Y1 - 2025/5/22
N2 - Consumption of mycotoxin-contaminated food is considered a main alimentary risk, with grave consequences on gastrointestinal function. Inflammatory bowel disease (IBD) is a complex, heterogeneous disorder of the gut, leading to severe abdominal pain, diarrhoea, and malnutrition. Similar indicators have been observed in foodborne mycotoxicosis. This review aims to elucidate the adverse effects of mycotoxin exposure on gut homeostasis and their correlation with IBD. We discuss latest research substantiating a role for mycotoxins in the pathogenesis of IBD, collating evidence of a crosstalk between mycotoxin-activated pathways and pathomechanisms of IBD. Considering the burden posed by IBD worldwide and the accelerating mycotoxin occurrence in global food commodities, we also propose future research directions to mitigate the harmful impact of mycotoxins on gut health.
AB - Consumption of mycotoxin-contaminated food is considered a main alimentary risk, with grave consequences on gastrointestinal function. Inflammatory bowel disease (IBD) is a complex, heterogeneous disorder of the gut, leading to severe abdominal pain, diarrhoea, and malnutrition. Similar indicators have been observed in foodborne mycotoxicosis. This review aims to elucidate the adverse effects of mycotoxin exposure on gut homeostasis and their correlation with IBD. We discuss latest research substantiating a role for mycotoxins in the pathogenesis of IBD, collating evidence of a crosstalk between mycotoxin-activated pathways and pathomechanisms of IBD. Considering the burden posed by IBD worldwide and the accelerating mycotoxin occurrence in global food commodities, we also propose future research directions to mitigate the harmful impact of mycotoxins on gut health.
U2 - 10.1016/j.cofs.2025.101316
DO - 10.1016/j.cofs.2025.101316
M3 - Article
SN - 2214-7993
VL - 64
SP - 1
EP - 11
JO - Current Opinion in Food Science
JF - Current Opinion in Food Science
M1 - 101316
ER -