Unravelling the impact of mycotoxins on gut health: implications for inflammatory bowel disease

Alessandra Marcon Gasperini; Danilo Faccenda; Esther Garcia-Cela

doi:10.1016/j.cofs.2025.101316

Unravelling the impact of mycotoxins on gut health: implications for inflammatory bowel disease

Alessandra Marcon Gasperini
, Danilo Faccenda
, Esther Garcia-Cela

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

23 Downloads (Pure)

Abstract

Consumption of mycotoxin-contaminated food is considered a main alimentary risk, with grave consequences on gastrointestinal function. Inflammatory bowel disease (IBD) is a complex, heterogeneous disorder of the gut, leading to severe abdominal pain, diarrhoea, and malnutrition. Similar indicators have been observed in foodborne mycotoxicosis. This review aims to elucidate the adverse effects of mycotoxin exposure on gut homeostasis and their correlation with IBD. We discuss latest research substantiating a role for mycotoxins in the pathogenesis of IBD, collating evidence of a crosstalk between mycotoxin-activated pathways and pathomechanisms of IBD. Considering the burden posed by IBD worldwide and the accelerating mycotoxin occurrence in global food commodities, we also propose future research directions to mitigate the harmful impact of mycotoxins on gut health.

Original language	English
Article number	101316
Pages (from-to)	1-11
Number of pages	11
Journal	Current Opinion in Food Science
Volume	64
Early online date	22 May 2025
DOIs	https://doi.org/10.1016/j.cofs.2025.101316
Publication status	Published - 30 Aug 2025

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© 2025 The Author(s). Published by Elsevier Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution - Non-Commercial 4.0 International License (CC BY-NC), https://creativecommons.org/licenses/by-nc/4.0/
Final published version, 3.03 MBLicence: CC BY-NC

Cite this

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title = "Unravelling the impact of mycotoxins on gut health: implications for inflammatory bowel disease",

abstract = "Consumption of mycotoxin-contaminated food is considered a main alimentary risk, with grave consequences on gastrointestinal function. Inflammatory bowel disease (IBD) is a complex, heterogeneous disorder of the gut, leading to severe abdominal pain, diarrhoea, and malnutrition. Similar indicators have been observed in foodborne mycotoxicosis. This review aims to elucidate the adverse effects of mycotoxin exposure on gut homeostasis and their correlation with IBD. We discuss latest research substantiating a role for mycotoxins in the pathogenesis of IBD, collating evidence of a crosstalk between mycotoxin-activated pathways and pathomechanisms of IBD. Considering the burden posed by IBD worldwide and the accelerating mycotoxin occurrence in global food commodities, we also propose future research directions to mitigate the harmful impact of mycotoxins on gut health.",

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AU - Garcia-Cela, Esther

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Unravelling the impact of mycotoxins on gut health: implications for inflammatory bowel disease

Abstract

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