Using randomised vectors in transcription factor binding site predictions

F. Rezwan, Yi. Sun, N. Davey, R.G. Adams, A.G. Rust, M. Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

58 Downloads (Pure)

Abstract

Finding the location of binding sites in DNA is a difficult problem. Although the location of some binding sites have been experimentally identified, other parts of the genome may or may not contain binding sites. This poses problems with negative data in a trainable classifier. Here we show that using randomized negative data gives a large boost in classifier performance when compared to the original labeled data.
Original languageEnglish
Title of host publicationProcs of 9th Int Conference on Machine Learning and Applications, ICMLA
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages523-527
ISBN (Print)978-1-4244-9211-4
DOIs
Publication statusPublished - 2010

Keywords

  • binding site
  • classification
  • genes
  • support vector machines

Fingerprint

Dive into the research topics of 'Using randomised vectors in transcription factor binding site predictions'. Together they form a unique fingerprint.

Cite this