TY - JOUR
T1 - Vesicles bearing gifts
T2 - the functional importance of micro-RNA transfer in extracellular vesicles in chronic kidney disease
AU - Abbasian, Nima
AU - Herbert, Karl E
AU - Pawluczyk, Izabella
AU - Burton, James O
AU - Bevington, Alan
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Extracellular vesicles (EVs), including microparticles (MPs) and exosomes (EXOs), are derived from a wide range of mammalian cells including blood platelets, endothelial cells, and kidney cells and can be detected in body fluids including blood and urine. While EVs are well established as diagnostic markers under pathophysiological and stress conditions, there is also mounting evidence of their functional significance as vehicles for communication between cells mediated by the presence of nucleic acids, especially microRNAs (miRs), encapsulated in the EVs. miRs regulate gene expression, are transported both in MPs and EXOs, and exert profound effects in the kidney. Here we review current understanding of the links between EVs and miRs, discuss the importance of miRs in kidney disease, and shed light on the role of EVs in transferring miRs through the circulation among the renal, vascular, and inflammatory cell populations that are functionally important in patients with chronic kidney disease.
AB - Extracellular vesicles (EVs), including microparticles (MPs) and exosomes (EXOs), are derived from a wide range of mammalian cells including blood platelets, endothelial cells, and kidney cells and can be detected in body fluids including blood and urine. While EVs are well established as diagnostic markers under pathophysiological and stress conditions, there is also mounting evidence of their functional significance as vehicles for communication between cells mediated by the presence of nucleic acids, especially microRNAs (miRs), encapsulated in the EVs. miRs regulate gene expression, are transported both in MPs and EXOs, and exert profound effects in the kidney. Here we review current understanding of the links between EVs and miRs, discuss the importance of miRs in kidney disease, and shed light on the role of EVs in transferring miRs through the circulation among the renal, vascular, and inflammatory cell populations that are functionally important in patients with chronic kidney disease.
KW - Animals
KW - Exosomes/genetics
KW - Gene Expression Regulation
KW - Humans
KW - Kidney/metabolism
KW - MicroRNAs/genetics
KW - Renal Insufficiency, Chronic/genetics
KW - Signal Transduction
U2 - 10.1152/ajprenal.00318.2018
DO - 10.1152/ajprenal.00318.2018
M3 - Review article
C2 - 30110570
SN - 1931-857X
VL - 315
SP - F1430-F1443
JO - American journal of physiology. Renal physiology
JF - American journal of physiology. Renal physiology
IS - 5
ER -