Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome

Sonia Gandhi, Mark A Little, Ken Farrington

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.

Original languageEnglish
Pages (from-to)591-6
Number of pages6
JournalRenal failure
Issue number5
Publication statusPublished - Sept 2004


  • Aged
  • Anti-Glomerular Basement Membrane Disease
  • Diagnosis, Differential
  • Female
  • Humans
  • Renal Insufficiency
  • Thrombocytopenia
  • Waldenstrom Macroglobulinemia
  • Case Reports
  • Journal Article
  • Review


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