Wegener's granulomatosis presenting as acute suppurative interstitial nephritis

A Banerjee, W McKane, S Thiru, K Farrington

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17 Citations (Scopus)


A 78 year old man presented with acute renal failure following a prolonged respiratory illness. A renal biopsy demonstrated severe suppurative interstitial nephritis with normal glomeruli. After nine weeks of antibiotics he remained anuric and a second biopsy demonstrated pauci-immune, necrotising glomerulonephritis. His subsequent clinical course was consistent with a diagnosis of Wegener's granulomatosis and antineutrophil cytoplasmic antibodies (ANCA) were detected. This is the first reported case of Wegener's granulomatosis presenting with an isolated tubulointerstitial lesion.

Original languageEnglish
Pages (from-to)787-9
Number of pages3
JournalJournal of Clinical Pathology
Issue number10
Publication statusPublished - Oct 2001


  • Acute Disease
  • Aged
  • Anti-Inflammatory Agents
  • Antibodies, Antineutrophil Cytoplasmic
  • Antibodies, Antinuclear
  • Biopsy
  • Cyclophosphamide
  • Granulomatosis with Polyangiitis
  • Humans
  • Immunosuppressive Agents
  • Male
  • Nephritis, Interstitial
  • Prednisone
  • Treatment Outcome
  • Case Reports
  • Journal Article


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