University of Hertfordshire

• The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy

  Moore, C., Kosgodage, U., Lange, S. & Inal, J. M., 1 Aug 2017, In: International Journal of Cancer. 141, 3, p. 428-436 9 p.

  Research output: Contribution to journal › Review article › peer-review

• Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?

  Lange, S., Gallagher, M., Kholia, S., Kosgodage, U. S., Hristova, M., Hardy, J. & Inal, J. M., 5 Jun 2017, In: International Journal of Molecular Sciences. 18, 6, 1196.

  Research output: Contribution to journal › Review article › peer-review

• Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

  Kosgodage, U. S., Trindade, R. P., Thompson, P. R., Inal, J. M. & Lange, S., 9 May 2017, In: International Journal of Molecular Sciences. 18, 5, 12 p., 1007.

  Research output: Contribution to journal › Article › peer-review

• Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro

  Evans-Osses, I., Mojoli, A., Monguió-Tortajada, M., Marcilla, A., Aran, V., Amorim, M., Inal, J., Borràs, F. E. & Ramirez, M. I., 31 Mar 2017, In: European journal of cell biology. 96, 2, p. 131-142 12 p.

  Research output: Contribution to journal › Article › peer-review

• Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology.

  Lange, S., Kholia, S., Kosgodage, U. S. & Inal, J., 2017, Protein Deimination in Human Health and Disease. Nicholas, A., Bhattacharya, S. & Thompson, P. (eds.). 2 ed. Springer, Cham, p. 413-425 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo

  Jorfi, S., Ansa-Addo, E. A., Kholia, S., Stratton, D., Valley, S., Lange, S. & Inal, J., 25 Aug 2015, In: Scientific Reports. 5, 13 p., 13006.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Microfabrication of conical microfunnels for drug delivery applications

  Liu, L. W. Y., Virdee, B. S., Inal, J. & Steer, M. B., 1 Jul 2015, In: Micro and Nano Letters. 10, 7, p. 355-357 3 p.

  Research output: Contribution to journal › Article › peer-review

• Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9

  Stratton, D., Moore, C., Antwi-Baffour, S., Lange, S. & Inal, J., 8 May 2015, In: Biochemical and Biophysical Research Communications. 460, 3, p. 589-595 7 p.

  Research output: Contribution to journal › Article › peer-review

• Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles

  Stratton, D., Moore, C., Zheng, L., Lange, S. & Inal, J., 8 May 2015, In: Biochemical and Biophysical Research Communications. 460, 3, p. 511-517 7 p.

  Research output: Contribution to journal › Article › peer-review

• A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

  Kholia, S., Jorfi, S., Thompson, P. R., Causey, C. P., Nicholas, A. P., Inal, J. M. & Lange, S., 22 Jun 2015, In: Journal of Extracellular Vesicles. 4, 1, 16 p., 26192.

  Research output: Contribution to journal › Article › peer-review

• Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis

  An, T., Qin, S., Xu, Y., Tang, Y., Huang, Y., Situ, B., Inal, J. M. & Zheng, L., 22 Jun 2015, In: Journal of Extracellular Vesicles. 4, 1, 27522.

  Research output: Contribution to journal › Review article › peer-review

• Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance

  Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S. & Inal, J., 24 Oct 2014, In: Biochemical and Biophysical Research Communications. 453, 3, p. 619-624 6 p.

  Research output: Contribution to journal › Article › peer-review

• Blood/plasma secretome and microvesicles

  Inal, J. M., Kosgodage, U., Azam, S., Stratton, D., Antwi-Baffour, S. & Lange, S., Nov 2013, In: Biochimica et Biophysica Acta - Biomembranes. 1834, 11, p. 2317-25 9 p.

  Research output: Contribution to journal › Review article › peer-review

• Entry in progress

  Coxsackievirus B transmission and possible new roles for extracellular vesicles

  Inal, J. M. & Jorfi, S., 1 Feb 2013, In: Biochemical Society Transactions. 41, 1, p. 299-302 4 p.

  Research output: Contribution to journal › Review article › peer-review

• Interplay of host-pathogen microvesicles and their role in infectious disease

  Inal, J. M., Ansa-Addo, E. A. & Lange, S., 1 Feb 2013, In: Biochemical Society Transactions. 41, 1, p. 258-62 5 p.

  Research output: Contribution to journal › Review article › peer-review

• Entry in progress

  Microvesiculation and disease

  Inal, J. M., Fairbrother, U. & Heugh, S., 1 Feb 2013, In: Biochemical Society Transactions. 41, 1, p. 237-40 4 p.

  Research output: Contribution to journal › Review article › peer-review

• The role of microvesicles in cancer progression and drug resistance

  Jorfi, S. & Inal, J. M., 1 Feb 2013, In: Biochemical Society Transactions. 41, 1, p. 293-8 6 p.

  Research output: Contribution to journal › Review article › peer-review

• Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells

  Stratton, D., Lange, S. & Inal, J. M., 11 Jan 2013, In: Biochemical and Biophysical Research Communications. 430, 2, p. 470-5 6 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Microvesicles in health and disease

  Inal, J. M., Ansa-Addo, E. A., Stratton, D., Kholia, S., Antwi-Baffour, S. S., Jorfi, S. & Lange, S., Apr 2012, In: Archivum Immunologiae et Therapiae Experimentalis. 60, 2, p. 107-21 15 p.

  Research output: Contribution to journal › Review article › peer-review

• Trypanosoma cruzi immune evasion mediated by host cell-derived microvesicles

  Cestari, I., Ansa-Addo, E., Deolindo, P., Inal, J. M. & Ramirez, M. I., 15 Feb 2012, In: Journal of Immunology. 188, 4, p. 1942-52 11 p.

  Research output: Contribution to journal › Article › peer-review

• Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

  Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J. M., Gabrielsson, S., Gho, Y. S., Gupta, D., Harsha, H. C., Hendrix, A. & 36 others, Hill, A. F., Inal, J. M., Jenster, G., Krämer-Albers, E-M., Lim, S. K., Llorente, A., Lötvall, J., Marcilla, A., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E. N. M., Pandey, A., Patel, T., Piper, M. G., Pluchino, S., Prasad, T. S. K., Rajendran, L., Raposo, G., Record, M., Reid, G. E., Sánchez-Madrid, F., Schiffelers, R. M., Siljander, P., Stensballe, A., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B. W. M., Vázquez, J., Vidal, M., Wauben, M. H. M., Yáñez-Mó, M., Zoeller, M. & Mathivanan, S., 18 Dec 2012, In: Plos Biology. 10, 12, p. e1001450

  Research output: Contribution to journal › Article › peer-review

• A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma

  Grant, R., Ansa-Addo, E., Stratton, D., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L., Lange, S. & Inal, J., 31 Aug 2011, In: Journal of Immunological Methods. 371, 1-2, p. 143-51 9 p.

  Research output: Contribution to journal › Article › peer-review

• Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells

  Ansa-Addo, E. A., Lange, S., Stratton, D., Antwi-Baffour, S., Cestari, I., Ramirez, M. I., McCrossan, M. V. & Inal, J. M., 1 Nov 2010, In: Journal of Immunology. 185, 9, p. 5236-46 11 p.

  Research output: Contribution to journal › Article › peer-review

• Red cell PMVs, plasma membrane-derived vesicles calling out for standards

  Hind, E., Heugh, S., Ansa-Addo, E. A., Antwi-Baffour, S., Lange, S. & Inal, J., 3 Sep 2010, In: Biochemical and Biophysical Research Communications. 399, 4, p. 465-9 5 p.

  Research output: Contribution to journal › Review article › peer-review

• Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells--possible role in SLE

  Antwi-Baffour, S., Kholia, S., Aryee, Y. K-D., Ansa-Addo, E. A., Stratton, D., Lange, S. & Inal, J. M., 23 Jul 2010, In: Biochemical and Biophysical Research Communications. 398, 2, p. 278-83 6 p.

  Research output: Contribution to journal › Article › peer-review

• Involvement of lectin pathway activation in the complement killing of Giardia intestinalis

  Evans-Osses, I., Ansa-Addo, E. A., Inal, J. M. & Ramirez, M. I., 7 May 2010, In: Biochemical and Biophysical Research Communications. 395, 3, p. 382-6 5 p.

  Research output: Contribution to journal › Article › peer-review

• Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi

  Cestari, I. D. S., Krarup, A., Sim, R. B., Inal, J. M. & Ramirez, M. I., 27 Aug 2009, In: Molecular immunology. 47, 2-3, p. 426-37 12 p.

  Research output: Contribution to journal › Article › peer-review

• Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi

  Cestari, I. D. S., Evans-Osses, I., Freitas, J. C., Inal, J. M. & Ramirez, M. I., 1 Nov 2008, In: Journal of Infectious Diseases. 198, 9, p. 1276-83 8 p.

  Research output: Contribution to journal › Article › peer-review

• CRIT is expressed on podocytes in normal human kidney and upregulated in membranous nephropathy

  Moll, S., Lange, S., Mihatsch, M. J., Dragic, Z., Schifferli, J. A. & Inal, J. M., 5 Apr 2006, (E-pub ahead of print) In: Kidney International. 69, 11, p. 1961-8 8 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Complement C2 receptor inhibitor trispanning: From man to schistosome

  Inal, J. M., Jun 2006, In: Springer seminars in immunopathology. 27, 4, p. 509-510 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Entry in progress

  CRIT peptide interacts with factor B and interferes with alternative pathway activation

  Hui, K. M., Magnadóttir, B., Schifferli, J. A. & Inal, J. M., 26 May 2006, In: Biochemical and Biophysical Research Communications. 344, 1, p. 308-314 7 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Complement C2 receptor inhibitor trispanning: from man to schistosome

  Inal, J. M., Nov 2005, In: Springer seminars in immunopathology. 27, 3, p. 320-31 12 p.

  Research output: Contribution to journal › Review article › peer-review

• Entry in progress

  The complement inhibitor, CRIT, undergoes clathrin-dependent endocytosis

  Inal, J., Miot, S. & Schifferli, J. A., 15 Oct 2005, In: Cell. 310, 1, p. 54-65 12 p.

  Research output: Contribution to journal › Article › peer-review

• Expression of functional recombinant von Willebrand factor-A domain from human complement C2: a potential binding site for C4 and CRIT

  Hui, K-M., Orriss, G. L., Schirmer, T., Magnadóttir, B., Schifferli, J. A. & Inal, J. M., 1 Aug 2005, In: Biochemical Journal. 389, Pt 3, p. 863-8 6 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Complement C2 receptor inhibitor trispanning: A novel human complement inhibitory receptor

  Inal, J. M., Hui, K. M., Miot, S., Lange, S., Ramirez, M. I., Schneider, B., Krueger, G. & Schifferli, J. A., 1 Jan 2005, In: Journal of Immunology. 174, 1, p. 356-366 11 p.

  Research output: Contribution to journal › Article › peer-review

• Complement mediates the binding of HIV to erythrocytes

  Horakova, E., Gasser, O., Sadallah, S., Inal, J. M., Bourgeois, G., Ziekau, I., Klimkait, T. & Schifferli, J. A., 15 Sep 2004, In: Journal of Immunology. 173, 6, p. 4236-41 6 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Parasite interaction with host complement: beyond attack regulation

  Inal, J. M., Sep 2004, In: Trends in Parasitology. 20, 9, p. 407-12 6 p.

  Research output: Contribution to journal › Review article › peer-review

• Entry in progress

  A peptide derived from the parasite receptor, complement C2 receptor inhibitor trispanning, suppresses immune complex-mediated inflammation in mice

  Inal, J. M., Schneider, B., Armanini, M. & Schifferli, J. A., 15 Apr 2003, In: Journal of Immunology. 170, 8, p. 4310-4317 8 p.

  Research output: Contribution to journal › Article › peer-review

• Complement inhibition in renal diseases

  Inal, J. M., Pascual, M., Lesavre, P. & Schifferli, J-A., Feb 2003, In: Nephrology Dialysis Transplantation. 18, 2, p. 237-40 4 p.

  Research output: Contribution to journal › Review article › peer-review

• Phage therapy: a reappraisal of bacteriophages as antibiotics

  Inal, J. M., 2003, In: Archivum Immunologiae et Therapiae Experimentalis. 51, 4, p. 237-44 8 p.

  Research output: Contribution to journal › Review article › peer-review

• Entry in progress

  Complement C2 receptor inhibitor trispanning and the β-chain of C4 share a binding site for complement C2

  Inal, J. M. & Schifferli, J. A., 15 May 2002, In: Journal of Immunology. 168, 10, p. 5213-5221 9 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2

  Inal, J. M. & Sim, R. B., 24 Mar 2000, In: FEBS Letters. 470, 2, p. 131-134 4 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Schistosoma TOR (trispanning orphan receptor), a novel, antigenic surface receptor of the blood-dwelling, Schistosoma parasite

  Inal, J. M., 9 Jun 1999, In: Biochimica et Biophysica Acta - Gene Structure and Expression. 1445, 3, p. 283-298 16 p.

  Research output: Contribution to journal › Article › peer-review

• Bacillus thuringiensis subsp. aizawai generalized transducing phage φHD248: Restriction site map and potential for fine-structure chromosomal mapping

  Inal, J. M., Karunakaran, V. & Jones, D. R., Jun 1996, In: Microbiology. 142, 6, p. 1409-1416 8 p.

  Research output: Contribution to journal › Article › peer-review

• φ20, a temperate bacteriophage isolated from Bacillus anthracis exists as a plasmidial prophage

  Inal, J. M. & Karunakaran, K. V., Apr 1996, In: Current Microbiology. 32, 4, p. 171-175 5 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Sequence and immunogenicity of the 23-kDa transmembrane antigen of Schistosoma haematobium

  Inal, J. & Bickle, Q., Nov 1995, In: Molecular and Biochemical Parasitology. 74, 2, p. 217-221 5 p.

  Research output: Contribution to journal › Article › peer-review

• Entry in progress

  Isolation and propagation of phages naturally associated with the aizawai variety of Bacillus thuringiensis

  Inal, J. R., Karunakaran, V. & Burges, H. D., Jan 1990, In: Journal of Applied Bacteriology. 68, 1, p. 17-21 5 p.

  Research output: Contribution to journal › Article › peer-review

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• FRSB

  Prize: Election to learned society

• University Hospital Basel Department of Biomedicine Research Prize

  Prize: Prize (including medals and awards)

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• Membrane vesicle-mediated sensitization of Clostridioides difficile to phage infection

  Project: Other

• Investigating the viability of Outer Membrane Vesicle Inhibition in sensitizing bacteria to phage therapy.

  Project: Other

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