University of Hertfordshire

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A comparison of methods to determine neuronal phase-response curves

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  • 907193

    Final published version, 1.9 MB, PDF document

  • Ben Torben-Nielsen
  • Marylka Uusisaari
  • Klaus M. Stiefel
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Original languageEnglish
Article number6
Number of pages11
JournalFrontiers in Neuroinformatics
Publication statusPublished - 2010


The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and experimental data and compare the numerically obtained results from each method. The main difference between the methods lies in the reliability which is influenced by the fluctuations in the spiking data and the number of spikes available for analysis. We discuss the significance of our results and provide guidelines to choose the best method based on the available data


© 2010 Torben-Nielsen, Uusisaari and Stiefel. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited

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