University of Hertfordshire

From the same journal

By the same authors


  • Shelly Coe
  • Thanasis G. Tektonidis
  • Clare Coverdale
  • Sarah Penny
  • Johnny Collett
  • Bernard T.Y. Chu
  • Hooshang Izadi
  • Rod Middleton
  • Helen Dawes
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Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalNutrition Research
Early online date20 Nov 2020
Publication statusPublished - Jan 2021


To assess the intake of nutrients in people with multiple sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 years)) provided dietary data using a food frequency questionnaire that was hosted on the MS Register for a period of 3 months and this was compared to a cohort of 24,852 controls (11,250 male, 13,602 female, mean age 59 years). Consent was implied by anonymously filling out the questionnaire. A Wilcoxon test was used to compare intake between pwMS and controls, and a bivariate analyses followed by chi2 test were undertaken to identify significance and the strength of the relationship between pro/anti-inflammatory dietary factors and fatigue and EQ-5D. Compared to controls, all nutrients were significantly lower in the MS group (P < .05). Bivariate associations showed a significant correlation between consuming fish and lower clinical fatigue (χ2(1) = 4.221, P< .05), with a very low association (φ (phi) = −0.051, P = .04. Positive health outcomes on the EQ-5D measures were associated with higher carotene, magnesium oily fish and fruits and vegetable and sodium consumption (P < .05). Fiber, red meat, and saturated fat (women only) consumption was associated with worse outcomes on the EQ-5D measures (P < .05). pwMS have different dietary intakes compared to controls, and this may be associated with worse symptoms.


Funding Information: Funding for this research was obtained from Oxford Brookes University. Professor Helen Dawes is supported by the Elizabeth Casson Trust and the NIHR Oxford Health Biomedical Research Centre. Publisher Copyright: © 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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