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A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry. / Coe, Shelly; Tektonidis, Thanasis G.; Coverdale, Clare; Penny, Sarah; Collett, Johnny; Chu, Bernard T.Y.; Izadi, Hooshang; Middleton, Rod; Dawes, Helen.

In: Nutrition Research, Vol. 85, 01.2021, p. 31-39.

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Coe, Shelly ; Tektonidis, Thanasis G. ; Coverdale, Clare ; Penny, Sarah ; Collett, Johnny ; Chu, Bernard T.Y. ; Izadi, Hooshang ; Middleton, Rod ; Dawes, Helen. / A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry. In: Nutrition Research. 2021 ; Vol. 85. pp. 31-39.

Bibtex

@article{7e4ecd2892634ef19bed00f86605033d,
title = "A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry",
abstract = "To assess the intake of nutrients in people with multiple sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 years)) provided dietary data using a food frequency questionnaire that was hosted on the MS Register for a period of 3 months and this was compared to a cohort of 24,852 controls (11,250 male, 13,602 female, mean age 59 years). Consent was implied by anonymously filling out the questionnaire. A Wilcoxon test was used to compare intake between pwMS and controls, and a bivariate analyses followed by chi2 test were undertaken to identify significance and the strength of the relationship between pro/anti-inflammatory dietary factors and fatigue and EQ-5D. Compared to controls, all nutrients were significantly lower in the MS group (P < .05). Bivariate associations showed a significant correlation between consuming fish and lower clinical fatigue (χ2(1) = 4.221, P< .05), with a very low association (φ (phi) = −0.051, P = .04. Positive health outcomes on the EQ-5D measures were associated with higher carotene, magnesium oily fish and fruits and vegetable and sodium consumption (P < .05). Fiber, red meat, and saturated fat (women only) consumption was associated with worse outcomes on the EQ-5D measures (P < .05). pwMS have different dietary intakes compared to controls, and this may be associated with worse symptoms.",
keywords = "Diet, Fatigue, Inflammation, Multiple sclerosis, Quality of life",
author = "Shelly Coe and Tektonidis, {Thanasis G.} and Clare Coverdale and Sarah Penny and Johnny Collett and Chu, {Bernard T.Y.} and Hooshang Izadi and Rod Middleton and Helen Dawes",
note = "Funding Information: Funding for this research was obtained from Oxford Brookes University. Professor Helen Dawes is supported by the Elizabeth Casson Trust and the NIHR Oxford Health Biomedical Research Centre. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.1016/j.nutres.2020.11.006",
language = "English",
volume = "85",
pages = "31--39",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry

AU - Coe, Shelly

AU - Tektonidis, Thanasis G.

AU - Coverdale, Clare

AU - Penny, Sarah

AU - Collett, Johnny

AU - Chu, Bernard T.Y.

AU - Izadi, Hooshang

AU - Middleton, Rod

AU - Dawes, Helen

N1 - Funding Information: Funding for this research was obtained from Oxford Brookes University. Professor Helen Dawes is supported by the Elizabeth Casson Trust and the NIHR Oxford Health Biomedical Research Centre. Publisher Copyright: © 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - To assess the intake of nutrients in people with multiple sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 years)) provided dietary data using a food frequency questionnaire that was hosted on the MS Register for a period of 3 months and this was compared to a cohort of 24,852 controls (11,250 male, 13,602 female, mean age 59 years). Consent was implied by anonymously filling out the questionnaire. A Wilcoxon test was used to compare intake between pwMS and controls, and a bivariate analyses followed by chi2 test were undertaken to identify significance and the strength of the relationship between pro/anti-inflammatory dietary factors and fatigue and EQ-5D. Compared to controls, all nutrients were significantly lower in the MS group (P < .05). Bivariate associations showed a significant correlation between consuming fish and lower clinical fatigue (χ2(1) = 4.221, P< .05), with a very low association (φ (phi) = −0.051, P = .04. Positive health outcomes on the EQ-5D measures were associated with higher carotene, magnesium oily fish and fruits and vegetable and sodium consumption (P < .05). Fiber, red meat, and saturated fat (women only) consumption was associated with worse outcomes on the EQ-5D measures (P < .05). pwMS have different dietary intakes compared to controls, and this may be associated with worse symptoms.

AB - To assess the intake of nutrients in people with multiple sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 years)) provided dietary data using a food frequency questionnaire that was hosted on the MS Register for a period of 3 months and this was compared to a cohort of 24,852 controls (11,250 male, 13,602 female, mean age 59 years). Consent was implied by anonymously filling out the questionnaire. A Wilcoxon test was used to compare intake between pwMS and controls, and a bivariate analyses followed by chi2 test were undertaken to identify significance and the strength of the relationship between pro/anti-inflammatory dietary factors and fatigue and EQ-5D. Compared to controls, all nutrients were significantly lower in the MS group (P < .05). Bivariate associations showed a significant correlation between consuming fish and lower clinical fatigue (χ2(1) = 4.221, P< .05), with a very low association (φ (phi) = −0.051, P = .04. Positive health outcomes on the EQ-5D measures were associated with higher carotene, magnesium oily fish and fruits and vegetable and sodium consumption (P < .05). Fiber, red meat, and saturated fat (women only) consumption was associated with worse outcomes on the EQ-5D measures (P < .05). pwMS have different dietary intakes compared to controls, and this may be associated with worse symptoms.

KW - Diet

KW - Fatigue

KW - Inflammation

KW - Multiple sclerosis

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=85099235482&partnerID=8YFLogxK

U2 - 10.1016/j.nutres.2020.11.006

DO - 10.1016/j.nutres.2020.11.006

M3 - Article

AN - SCOPUS:85099235482

VL - 85

SP - 31

EP - 39

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

ER -