University of Hertfordshire

A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension

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Documents

  • Nura A. Mohamed
  • Blerina Ahmetaj-Shala
  • Lucie Duluc
  • Louise S. Mackenzie
  • Nicholas S. Kirkby
  • Daniel M. Reed
  • Paul D. Lickiss
  • Robert P. Davies
  • Gemma R. Freeman
  • Beata Wojciak-Stothard
  • Adrian H. Chester
  • Ibrahim M. El-Sherbiny
  • Jane A. Mitchell
  • Magdi H. Yacoub
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Original languageEnglish
Pages (from-to)162-164
JournalJournal of Cardiovascular Translational Research
Volume9
Issue2
Early online date9 Mar 2016
DOIs
Publication statusPublished - Apr 2016

Abstract

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and progression of the disease. Its extremely short half-life and systemic effects have hampered the clinical use of NO in PAH. In an attempt to circumvent these major limitations, we have developed a new NO-nanomedicine formulation. The formulation was based on hydrogel-like polymeric composite NO-releasing nanoparticles (NO-RP). The kinetics of NO release from the NO-RP showed a peak at about 120 min followed by a sustained release for over 8 h. The NO-RP did not affect the viability or inflammation responses of endothelial cells. The NO-RP produced concentration-dependent relaxations of pulmonary arteries in mice with PAH induced by hypoxia. In conclusion, NO-RP drugs could considerably enhance the therapeutic potential of NO therapy for PAH.

Notes

Copyright The Author(s) 2016. This article is published with open access at Springerlink.com. Open Access - This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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