University of Hertfordshire


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Original languageEnglish
Article numbere13407
Number of pages24
JournalEuropean Journal of Cancer Care
Early online date16 Mar 2021
Publication statusPublished - 1 Jul 2021


Objectives: To explore factors contributing to decisions to transfuse platelets in cancer care outside guidelines using case study methods.

Methods: Two case studies were examined, using instrumental case study methodology, to qualitatively explore factors that influence the decision to transfuse platelets. Interviews (n=10) were conducted around cases in haematology and critical care. In-depth review of documentary evidence was undertaken and propositions were developed to provide rigour during the investigation. Thematic analysis and triangulation of documents was undertaken to find specific factors, and propositions analysed, as per instrumental case study methods.

Results: Both cases emphasised how patient complexity, and individual response to platelet administration, was an influencing factor. Other themes included uncertainty of clinical situations coupled with uncertainty about platelet availability. Other factors worthy of further investigation include the concept of professional safety and the trustworthiness of platelet thresholds against platelet monitoring for bleeding episodes.

Conclusion: The findings indicated several factors influence decisions to transfuse, including clinical context, and individual ability to trust guidelines and assume any perceived risks.


© 2021 John Wiley & Sons, Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at

ID: 18922719