University of Hertfordshire

From the same journal

By the same authors

  • Lindsay Hewison
  • Tony R Johnson
  • Brian E Mann
  • Anthony J H M Meijer
  • Philip Sawle
  • Roberto Motterlini
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Original languageEnglish
Pages (from-to)8328-34
Number of pages7
JournalDalton Transactions
Volume40
Issue33
DOIs
Publication statusPublished - 7 Sep 2011

Abstract

[Fe(L-cysteinate)(2)(CO)(2)](2-) is a CO releasing molecule which has low cytotoxicity to RAW264.7 macrophages. It provides an example of CO binding using ligands available to ion channels which use CO as a signalling molecule in the absence of heme. Previous work has shown that this compound consists of five isomers and it was proposed that the two isomers with trans-dicarbonyls are dominant. In this work the isomers are re-assigned and shown to be capable of releasing CO, albeit too slowly to act as a signalling receptor. It is shown that by linking the two L-cysteines together to form [Fe(SCH(2)CH{CO(2)H}NHCH(2))(2)(CO)(2)], only one isomer is isolated.

ID: 13575571