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A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans

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A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans. / Prevete, Elisabeth; Kuypers, Kim Paula Colette; Theunissen, Eef Lien; Corazza, Ornella; Bersani, Giuseppe; Ramaekers, Johannes Gerardus.

In: Human Psychopharmacology, 26.07.2021.

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Prevete, Elisabeth ; Kuypers, Kim Paula Colette ; Theunissen, Eef Lien ; Corazza, Ornella ; Bersani, Giuseppe ; Ramaekers, Johannes Gerardus. / A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans. In: Human Psychopharmacology. 2021.

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@article{8239d6d8042245c6a5c7a41a5aaf4983,
title = "A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans",
abstract = "INTRODUCTION: Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an ethnomedicinal remedy for several conditions in South East Asia. Despite the increased interest in its therapeutical benefits in Western countries, little scientific evidence is available to support such claims, and existing data remain limited to kratom's chronic consumption.OBJECTIVE: Our study aims to investigate (pre)clinical evidence on the efficacy of kratom as a therapeutic aid and its safety profile in humans.METHODS: A systematic literature search using PubMed and the Medline database was conducted between April and November 2020.RESULTS: Both preclinical (N = 57) and clinical (N = 18) studies emerged from our search. Preclinical data indicated a therapeutic value in terms of acute/chronic pain (N = 23), morphine/ethanol withdrawal, and dependence (N = 14), among other medical conditions (N = 26). Clinical data included interventional studies (N = 2) reporting reduced pain sensitivity, and observational studies (N = 9) describing the association between kratom's chronic (daily/frequent) use and safety issues, in terms of health consequences (e.g., learning impairment, high cholesterol level, dependence/withdrawal).CONCLUSIONS: Although the initial (pre)clinical evidence on kratom's therapeutic potential and its safety profile in humans is encouraging, further validation in large, controlled clinical trials is required.",
author = "Elisabeth Prevete and Kuypers, {Kim Paula Colette} and Theunissen, {Eef Lien} and Ornella Corazza and Giuseppe Bersani and Ramaekers, {Johannes Gerardus}",
note = "{\textcopyright} 2021 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, https://creativecommons.org/licenses/by-nc/4.0/.",
year = "2021",
month = jul,
day = "26",
doi = "10.1002/hup.2805",
language = "English",
journal = "Human Psychopharmacology: Clinical and Experimental",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",

}

RIS

TY - JOUR

T1 - A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans

AU - Prevete, Elisabeth

AU - Kuypers, Kim Paula Colette

AU - Theunissen, Eef Lien

AU - Corazza, Ornella

AU - Bersani, Giuseppe

AU - Ramaekers, Johannes Gerardus

N1 - © 2021 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, https://creativecommons.org/licenses/by-nc/4.0/.

PY - 2021/7/26

Y1 - 2021/7/26

N2 - INTRODUCTION: Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an ethnomedicinal remedy for several conditions in South East Asia. Despite the increased interest in its therapeutical benefits in Western countries, little scientific evidence is available to support such claims, and existing data remain limited to kratom's chronic consumption.OBJECTIVE: Our study aims to investigate (pre)clinical evidence on the efficacy of kratom as a therapeutic aid and its safety profile in humans.METHODS: A systematic literature search using PubMed and the Medline database was conducted between April and November 2020.RESULTS: Both preclinical (N = 57) and clinical (N = 18) studies emerged from our search. Preclinical data indicated a therapeutic value in terms of acute/chronic pain (N = 23), morphine/ethanol withdrawal, and dependence (N = 14), among other medical conditions (N = 26). Clinical data included interventional studies (N = 2) reporting reduced pain sensitivity, and observational studies (N = 9) describing the association between kratom's chronic (daily/frequent) use and safety issues, in terms of health consequences (e.g., learning impairment, high cholesterol level, dependence/withdrawal).CONCLUSIONS: Although the initial (pre)clinical evidence on kratom's therapeutic potential and its safety profile in humans is encouraging, further validation in large, controlled clinical trials is required.

AB - INTRODUCTION: Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an ethnomedicinal remedy for several conditions in South East Asia. Despite the increased interest in its therapeutical benefits in Western countries, little scientific evidence is available to support such claims, and existing data remain limited to kratom's chronic consumption.OBJECTIVE: Our study aims to investigate (pre)clinical evidence on the efficacy of kratom as a therapeutic aid and its safety profile in humans.METHODS: A systematic literature search using PubMed and the Medline database was conducted between April and November 2020.RESULTS: Both preclinical (N = 57) and clinical (N = 18) studies emerged from our search. Preclinical data indicated a therapeutic value in terms of acute/chronic pain (N = 23), morphine/ethanol withdrawal, and dependence (N = 14), among other medical conditions (N = 26). Clinical data included interventional studies (N = 2) reporting reduced pain sensitivity, and observational studies (N = 9) describing the association between kratom's chronic (daily/frequent) use and safety issues, in terms of health consequences (e.g., learning impairment, high cholesterol level, dependence/withdrawal).CONCLUSIONS: Although the initial (pre)clinical evidence on kratom's therapeutic potential and its safety profile in humans is encouraging, further validation in large, controlled clinical trials is required.

U2 - 10.1002/hup.2805

DO - 10.1002/hup.2805

M3 - Review article

C2 - 34309900

JO - Human Psychopharmacology: Clinical and Experimental

JF - Human Psychopharmacology: Clinical and Experimental

SN - 0885-6222

M1 - e2805

ER -