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By the same authors

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology

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An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology. / Bading, Bayissi; Bouckandou, M; De Souza, Alain; Bourobou Bourobou, H.P.; MacKenzie, Louise; Lione, Lisa.

In: Journal of Ethno-pharmacology, Vol. 216, 24.04.2018, p. 203-228.

Research output: Contribution to journalReview articlepeer-review

Harvard

Bading, B, Bouckandou, M, De Souza, A, Bourobou Bourobou, HP, MacKenzie, L & Lione, L 2018, 'An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology', Journal of Ethno-pharmacology, vol. 216, pp. 203-228. https://doi.org/10.1016/j.jep.2017.12.036

APA

Bading, B., Bouckandou, M., De Souza, A., Bourobou Bourobou, H. P., MacKenzie, L., & Lione, L. (2018). An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology. Journal of Ethno-pharmacology, 216, 203-228. https://doi.org/10.1016/j.jep.2017.12.036

Vancouver

Author

Bading, Bayissi ; Bouckandou, M ; De Souza, Alain ; Bourobou Bourobou, H.P. ; MacKenzie, Louise ; Lione, Lisa. / An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology. In: Journal of Ethno-pharmacology. 2018 ; Vol. 216. pp. 203-228.

Bibtex

@article{7101216c6ef84f6181287a75df80b0a1,
title = "An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology",
abstract = "Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including {\textquoteleft}Diabetes{\textquoteright} {\textquoteleft}Gabon{\textquoteright} {\textquoteleft}Toxicity{\textquoteright} {\textquoteleft}Constituents{\textquoteright} {\textquoteleft}hyperglycaemia{\textquoteright} were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.",
keywords = "Anti-diabetic activity, Diabetes mellitus, Gabon, Medicinal plants, Toxicity",
author = "Bayissi Bading and M Bouckandou and {De Souza}, Alain and {Bourobou Bourobou}, H.P. and Louise MacKenzie and Lisa Lione",
note = "{\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2018",
month = apr,
day = "24",
doi = "10.1016/j.jep.2017.12.036",
language = "English",
volume = "216",
pages = "203--228",
journal = "Journal of Ethno-pharmacology",
issn = "0378-8741",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology

AU - Bading, Bayissi

AU - Bouckandou, M

AU - De Souza, Alain

AU - Bourobou Bourobou, H.P.

AU - MacKenzie, Louise

AU - Lione, Lisa

N1 - © 2017 Elsevier B.V. All rights reserved.

PY - 2018/4/24

Y1 - 2018/4/24

N2 - Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including ‘Diabetes’ ‘Gabon’ ‘Toxicity’ ‘Constituents’ ‘hyperglycaemia’ were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.

AB - Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including ‘Diabetes’ ‘Gabon’ ‘Toxicity’ ‘Constituents’ ‘hyperglycaemia’ were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.

KW - Anti-diabetic activity

KW - Diabetes mellitus

KW - Gabon

KW - Medicinal plants

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85041522081&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2017.12.036

DO - 10.1016/j.jep.2017.12.036

M3 - Review article

VL - 216

SP - 203

EP - 228

JO - Journal of Ethno-pharmacology

JF - Journal of Ethno-pharmacology

SN - 0378-8741

ER -