University of Hertfordshire

An Overview of Tissue Engineering as an Alternative for Toxicity Assessment

Research output: Contribution to journalArticlepeer-review


  • Mathew Garrod
  • David Y.S. Chau
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Original languageEnglish
Pages (from-to)31-71
Number of pages40
JournalJournal of Pharmacy & Pharmaceutical Sciences
Publication statusPublished - 30 Jan 2016


Tissue engineering is a multidisciplinary field that combines aspects of biology, material sciences, engineering and medicine - the ultimate goal being able to fabricate replacement tissues and/or organs for an ageing population. However, parallel to this milestone, is the exploitation of the biomimetic constructs as
feasible alternatives to in vivo/ex vivo toxicity testing models due to their accurate representation of innate tissue and organs. Herein, we summarise a range of concepts within tissue engineering with a particular emphasis on biological material selection and implications to animal testing

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