University of Hertfordshire

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By the same authors

Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome

Research output: Contribution to journalArticlepeer-review


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Original languageEnglish
Number of pages14
JournalJournal of Clinical Medicine
Early online date27 Jun 2020
Publication statusPublished - 1 Jul 2020


Abstract: Acute coronary syndrome and atrial fibrillation are both common, and can occur in the same patient. Combination therapy with dual antiplatelet therapy and oral anticoagulation increases risk of bleeding. Where the two conditions co-exist, careful consideration is needed to determine the optimal antithrombotic treatment to reduce the risks of future ischaemic events associated with both conditions. Choices can be made in intraprocedural anticoagulation, type and dosing of oral anticoagulant, duration of combination therapy, and selection of P2Y12 inhibitor including genetic testing. This review article provides an overview of the available evidence to support clinicians in finding the delicate balance between antithrombotic efficacy and bleeding risk in patients with acute coronary syndrome and atrial fibrillation.


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