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Arterial Thrombus Stability: Does It Matter and Can We Detect It?

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Arterial Thrombus Stability : Does It Matter and Can We Detect It? / Gorog, Diana A; Fayad, Zahi A; Fuster, Valentin.

In: Journal of the American College of Cardiology, Vol. 70, No. 16, 17.10.2017, p. 2036-2047.

Research output: Contribution to journalReview articlepeer-review

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Gorog, Diana A ; Fayad, Zahi A ; Fuster, Valentin. / Arterial Thrombus Stability : Does It Matter and Can We Detect It?. In: Journal of the American College of Cardiology. 2017 ; Vol. 70, No. 16. pp. 2036-2047.

Bibtex

@article{64bf33a45b65468696d05b462eb01159,
title = "Arterial Thrombus Stability: Does It Matter and Can We Detect It?",
abstract = "The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence linking impaired spontaneous fibrinolytic activity with acute coronary events. We summarize experimental evidence for the importance of thrombus stability and highlight the need for physiologically relevant tests to assess spontaneous disintegration/fibrinolysis of platelet-rich thrombi under arterial flow conditions, review techniques to assess thrombus stability in vitro, and describe novel imaging techniques to characterize thrombosis in vivo. Such techniques may allow tailoring of pharmacotherapy to potentiate thrombus instability, through fragmentation of platelet thrombi and/or enhanced endogenous fibrinolysis, to reduce infarct size.",
keywords = "Coronary Thrombosis, Fibrinolysis, Humans, Magnetic Resonance Imaging, Cine, Multimodal Imaging, Thrombolytic Therapy, Thrombosis, Journal Article, Review",
author = "Gorog, {Diana A} and Fayad, {Zahi A} and Valentin Fuster",
note = "{\textcopyright} 2017 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION.PUBLISHED BY ELSEVIER. ALL RIGHTS RESERVED",
year = "2017",
month = oct,
day = "17",
doi = "10.1016/j.jacc.2017.08.065",
language = "English",
volume = "70",
pages = "2036--2047",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "16",

}

RIS

TY - JOUR

T1 - Arterial Thrombus Stability

T2 - Does It Matter and Can We Detect It?

AU - Gorog, Diana A

AU - Fayad, Zahi A

AU - Fuster, Valentin

N1 - © 2017 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION.PUBLISHED BY ELSEVIER. ALL RIGHTS RESERVED

PY - 2017/10/17

Y1 - 2017/10/17

N2 - The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence linking impaired spontaneous fibrinolytic activity with acute coronary events. We summarize experimental evidence for the importance of thrombus stability and highlight the need for physiologically relevant tests to assess spontaneous disintegration/fibrinolysis of platelet-rich thrombi under arterial flow conditions, review techniques to assess thrombus stability in vitro, and describe novel imaging techniques to characterize thrombosis in vivo. Such techniques may allow tailoring of pharmacotherapy to potentiate thrombus instability, through fragmentation of platelet thrombi and/or enhanced endogenous fibrinolysis, to reduce infarct size.

AB - The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence linking impaired spontaneous fibrinolytic activity with acute coronary events. We summarize experimental evidence for the importance of thrombus stability and highlight the need for physiologically relevant tests to assess spontaneous disintegration/fibrinolysis of platelet-rich thrombi under arterial flow conditions, review techniques to assess thrombus stability in vitro, and describe novel imaging techniques to characterize thrombosis in vivo. Such techniques may allow tailoring of pharmacotherapy to potentiate thrombus instability, through fragmentation of platelet thrombi and/or enhanced endogenous fibrinolysis, to reduce infarct size.

KW - Coronary Thrombosis

KW - Fibrinolysis

KW - Humans

KW - Magnetic Resonance Imaging, Cine

KW - Multimodal Imaging

KW - Thrombolytic Therapy

KW - Thrombosis

KW - Journal Article

KW - Review

U2 - 10.1016/j.jacc.2017.08.065

DO - 10.1016/j.jacc.2017.08.065

M3 - Review article

C2 - 29025561

VL - 70

SP - 2036

EP - 2047

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 16

ER -