University of Hertfordshire

From the same journal

By the same authors

  • Hamid A. Merchant
  • Emma L. McConnell
  • Fang Liu
  • Chandrasekaran Ramaswamy
  • Rucha P. Kulkarni
  • Abdul W. Basit
  • Sudaxshina Murdan
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Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalEuropean Journal of Pharmaceutical Sciences
Volume42
Issue1-2
DOIs
Publication statusPublished - 18 Jan 2011

Abstract

Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem in healthy guinea pigs, rabbits and pigs, to assess their suitability for pre-clinical studies by comparing the results with reported human literature. The mean gastric pH (fed ad libitum) was 2.9 and 4.4 in guinea pig and pig, respectively. In contrast, a very low pH (1.6) was recorded in the rabbits. The small intestinal pH was found in the range of 6.4-7.4 in the guinea pigs and rabbits, whereas lower pH (6.1-6.7) was recorded in the pig, which may have consequences for ionisable or pH responsive systems when tested in pig. A relatively lower pH than in the small intestine was found in the caecum (6.0-6.4) and colon (6.1-6.6) of the guinea pig, rabbit and the pig. The water content in the gastrointestinal tract of guinea pig, rabbit and pig was 51g, 153g and 1546g, respectively. When normalized to the body weight, the guinea pig, had larger amounts of water compared to the rabbit and the pig (guinea pig>rabbit>pig); in contrast, a reverse order was found when normalized to per unit length of the gut (guinea pig)

Notes

Copyright © 2010 Elsevier B.V. All rights reserved.

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