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Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development. / Merchant, Hamid A.; McConnell, Emma L.; Liu, Fang; Ramaswamy, Chandrasekaran; Kulkarni, Rucha P.; Basit, Abdul W.; Murdan, Sudaxshina.

In: European Journal of Pharmaceutical Sciences, Vol. 42, No. 1-2, 18.01.2011, p. 3-10.

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Merchant, Hamid A. ; McConnell, Emma L. ; Liu, Fang ; Ramaswamy, Chandrasekaran ; Kulkarni, Rucha P. ; Basit, Abdul W. ; Murdan, Sudaxshina. / Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development. In: European Journal of Pharmaceutical Sciences. 2011 ; Vol. 42, No. 1-2. pp. 3-10.

Bibtex

@article{445f406746f24b6090f8e69d9862866c,
title = "Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development",
abstract = "Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem in healthy guinea pigs, rabbits and pigs, to assess their suitability for pre-clinical studies by comparing the results with reported human literature. The mean gastric pH (fed ad libitum) was 2.9 and 4.4 in guinea pig and pig, respectively. In contrast, a very low pH (1.6) was recorded in the rabbits. The small intestinal pH was found in the range of 6.4-7.4 in the guinea pigs and rabbits, whereas lower pH (6.1-6.7) was recorded in the pig, which may have consequences for ionisable or pH responsive systems when tested in pig. A relatively lower pH than in the small intestine was found in the caecum (6.0-6.4) and colon (6.1-6.6) of the guinea pig, rabbit and the pig. The water content in the gastrointestinal tract of guinea pig, rabbit and pig was 51g, 153g and 1546g, respectively. When normalized to the body weight, the guinea pig, had larger amounts of water compared to the rabbit and the pig (guinea pig>rabbit>pig); in contrast, a reverse order was found when normalized to per unit length of the gut (guinea pig)",
keywords = "Body Fluids, Models, Animal, Swine, Animals, Guinea Pigs, Hydrogen-Ion Concentration, Rabbits, Drug Design, Lymphoid Tissue, Drug Evaluation, Preclinical, Species Specificity, Male, Gastrointestinal Tract",
author = "Merchant, {Hamid A.} and McConnell, {Emma L.} and Fang Liu and Chandrasekaran Ramaswamy and Kulkarni, {Rucha P.} and Basit, {Abdul W.} and Sudaxshina Murdan",
note = "Copyright {\textcopyright} 2010 Elsevier B.V. All rights reserved.",
year = "2011",
month = jan,
day = "18",
doi = "10.1016/j.ejps.2010.09.019",
language = "English",
volume = "42",
pages = "3--10",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development

AU - Merchant, Hamid A.

AU - McConnell, Emma L.

AU - Liu, Fang

AU - Ramaswamy, Chandrasekaran

AU - Kulkarni, Rucha P.

AU - Basit, Abdul W.

AU - Murdan, Sudaxshina

N1 - Copyright © 2010 Elsevier B.V. All rights reserved.

PY - 2011/1/18

Y1 - 2011/1/18

N2 - Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem in healthy guinea pigs, rabbits and pigs, to assess their suitability for pre-clinical studies by comparing the results with reported human literature. The mean gastric pH (fed ad libitum) was 2.9 and 4.4 in guinea pig and pig, respectively. In contrast, a very low pH (1.6) was recorded in the rabbits. The small intestinal pH was found in the range of 6.4-7.4 in the guinea pigs and rabbits, whereas lower pH (6.1-6.7) was recorded in the pig, which may have consequences for ionisable or pH responsive systems when tested in pig. A relatively lower pH than in the small intestine was found in the caecum (6.0-6.4) and colon (6.1-6.6) of the guinea pig, rabbit and the pig. The water content in the gastrointestinal tract of guinea pig, rabbit and pig was 51g, 153g and 1546g, respectively. When normalized to the body weight, the guinea pig, had larger amounts of water compared to the rabbit and the pig (guinea pig>rabbit>pig); in contrast, a reverse order was found when normalized to per unit length of the gut (guinea pig)

AB - Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem in healthy guinea pigs, rabbits and pigs, to assess their suitability for pre-clinical studies by comparing the results with reported human literature. The mean gastric pH (fed ad libitum) was 2.9 and 4.4 in guinea pig and pig, respectively. In contrast, a very low pH (1.6) was recorded in the rabbits. The small intestinal pH was found in the range of 6.4-7.4 in the guinea pigs and rabbits, whereas lower pH (6.1-6.7) was recorded in the pig, which may have consequences for ionisable or pH responsive systems when tested in pig. A relatively lower pH than in the small intestine was found in the caecum (6.0-6.4) and colon (6.1-6.6) of the guinea pig, rabbit and the pig. The water content in the gastrointestinal tract of guinea pig, rabbit and pig was 51g, 153g and 1546g, respectively. When normalized to the body weight, the guinea pig, had larger amounts of water compared to the rabbit and the pig (guinea pig>rabbit>pig); in contrast, a reverse order was found when normalized to per unit length of the gut (guinea pig)

KW - Body Fluids

KW - Models, Animal

KW - Swine

KW - Animals

KW - Guinea Pigs

KW - Hydrogen-Ion Concentration

KW - Rabbits

KW - Drug Design

KW - Lymphoid Tissue

KW - Drug Evaluation, Preclinical

KW - Species Specificity

KW - Male

KW - Gastrointestinal Tract

U2 - 10.1016/j.ejps.2010.09.019

DO - 10.1016/j.ejps.2010.09.019

M3 - Article

C2 - 20932902

VL - 42

SP - 3

EP - 10

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

IS - 1-2

ER -