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Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology. / Mohylyuk, Valentyn; Styliari, Ioanna Danai; Novykov, Dmytryi; Pikett, Reiss; Dattani, Rajeev.

In: Journal of Drug Delivery Science and Technology, Vol. 54, 101320, 12.2019.

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Mohylyuk, Valentyn ; Styliari, Ioanna Danai ; Novykov, Dmytryi ; Pikett, Reiss ; Dattani, Rajeev. / Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology. In: Journal of Drug Delivery Science and Technology. 2019 ; Vol. 54.

Bibtex

@article{48315c9f88a4453281e4b2a77f378ae4,
title = "Assessment of the effect of Cellets{\textquoteright} particle size on the flow in a Wurster fluid-bed coater via powder rheology",
abstract = "The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets{\textquoteright} size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster fluid-bed coater is used. The particle size distribution of Cellets was determined using optical digital microscopy. Standard pharmacopoeia methods as bulk/tapped density and flow rate measured with gravitational funnel method as well as investigation of dynamic angle of repose and dynamic cohesivity index with a rotating drum tester (GranuDrum) and conditioned bulk density, basic flowability energy, specific energy, pressure drop, permeability and compressibility by powder rheometer (FT4 Powder Rheometer{\textregistered}), were employed to characterise the powder's properties of Cellets 90, 100, 200 and 350 (D 50-size from 94 to 424 μm) alone or premixed with 0.5% w/w magnesium stearate. Specific powder rheology methods were proposed for characterisation of Cellets{\textquoteright} behaviour in down-flow bed, the horizontal transport and coating zone. The level of Cellets{\textquoteright} processability decreasing in the Wurster fluid-bed coater with decreasing of Cellets size (D 50) from 425 to 94 μm was established with different powder rheology methods. ",
keywords = "Cellets, Coating, Flowability, Fluid-bed, Pellets, Powder rheology, Processability",
author = "Valentyn Mohylyuk and Styliari, {Ioanna Danai} and Dmytryi Novykov and Reiss Pikett and Rajeev Dattani",
note = "{\textcopyright} 2019 Elsevier B.V. This manuscript is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). For further details please see: https://creativecommons.org/licenses/by-nc-nd/4.0/ ",
year = "2019",
month = dec,
doi = "10.1016/j.jddst.2019.101320",
language = "English",
volume = "54",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology

AU - Mohylyuk, Valentyn

AU - Styliari, Ioanna Danai

AU - Novykov, Dmytryi

AU - Pikett, Reiss

AU - Dattani, Rajeev

N1 - © 2019 Elsevier B.V. This manuscript is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). For further details please see: https://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2019/12

Y1 - 2019/12

N2 - The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster fluid-bed coater is used. The particle size distribution of Cellets was determined using optical digital microscopy. Standard pharmacopoeia methods as bulk/tapped density and flow rate measured with gravitational funnel method as well as investigation of dynamic angle of repose and dynamic cohesivity index with a rotating drum tester (GranuDrum) and conditioned bulk density, basic flowability energy, specific energy, pressure drop, permeability and compressibility by powder rheometer (FT4 Powder Rheometer®), were employed to characterise the powder's properties of Cellets 90, 100, 200 and 350 (D 50-size from 94 to 424 μm) alone or premixed with 0.5% w/w magnesium stearate. Specific powder rheology methods were proposed for characterisation of Cellets’ behaviour in down-flow bed, the horizontal transport and coating zone. The level of Cellets’ processability decreasing in the Wurster fluid-bed coater with decreasing of Cellets size (D 50) from 425 to 94 μm was established with different powder rheology methods.

AB - The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster fluid-bed coater is used. The particle size distribution of Cellets was determined using optical digital microscopy. Standard pharmacopoeia methods as bulk/tapped density and flow rate measured with gravitational funnel method as well as investigation of dynamic angle of repose and dynamic cohesivity index with a rotating drum tester (GranuDrum) and conditioned bulk density, basic flowability energy, specific energy, pressure drop, permeability and compressibility by powder rheometer (FT4 Powder Rheometer®), were employed to characterise the powder's properties of Cellets 90, 100, 200 and 350 (D 50-size from 94 to 424 μm) alone or premixed with 0.5% w/w magnesium stearate. Specific powder rheology methods were proposed for characterisation of Cellets’ behaviour in down-flow bed, the horizontal transport and coating zone. The level of Cellets’ processability decreasing in the Wurster fluid-bed coater with decreasing of Cellets size (D 50) from 425 to 94 μm was established with different powder rheology methods.

KW - Cellets

KW - Coating

KW - Flowability

KW - Fluid-bed

KW - Pellets

KW - Powder rheology

KW - Processability

UR - http://www.scopus.com/inward/record.url?scp=85073152862&partnerID=8YFLogxK

U2 - 10.1016/j.jddst.2019.101320

DO - 10.1016/j.jddst.2019.101320

M3 - Article

VL - 54

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

M1 - 101320

ER -