University of Hertfordshire

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Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer. / D'Andrea, David; Black, Peter C; Zargar, Homayoun; Zargar-Shoshtari, Kamran; Soria, Francesco; Fairey, Adrian S; Mertens, Laura S; Dinney, Colin P; Mir, Maria C; Krabbe, Laura-Maria; Cookson, Michael S; Jacobsen, Niels-Erik; Montgomery, Jeffrey S; Vasdev, Nikhil; Yu, Evan Y; Xylinas, Evanguelos; Campain, Nicholas J; Kassouf, Wassim; Dall'Era, Marc A; Seah, Jo-An; Ercole, Cesar E; Horenblas, Simon; Sridhar, Srikala S; McGrath, John S; Aning, Jonathan; Wright, Jonathan L; Thorpe, Andrew C; Morgan, Todd M; Holzbeierlein, Jeff M; Bivalacqua, Trinity J; North, Scott; Barocas, Daniel A; Lotan, Yair; Grivas, Petros; Stephenson, Andrew J; Shah, Jay B; van Rhijn, Bas W; Daneshmand, Siamak; Spiess, Philippe E; Shariat, Shahrokh F.

In: World Journal of Urology, 09.08.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

D'Andrea, D, Black, PC, Zargar, H, Zargar-Shoshtari, K, Soria, F, Fairey, AS, Mertens, LS, Dinney, CP, Mir, MC, Krabbe, L-M, Cookson, MS, Jacobsen, N-E, Montgomery, JS, Vasdev, N, Yu, EY, Xylinas, E, Campain, NJ, Kassouf, W, Dall'Era, MA, Seah, J-A, Ercole, CE, Horenblas, S, Sridhar, SS, McGrath, JS, Aning, J, Wright, JL, Thorpe, AC, Morgan, TM, Holzbeierlein, JM, Bivalacqua, TJ, North, S, Barocas, DA, Lotan, Y, Grivas, P, Stephenson, AJ, Shah, JB, van Rhijn, BW, Daneshmand, S, Spiess, PE & Shariat, SF 2021, 'Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer', World Journal of Urology. https://doi.org/10.1007/s00345-021-03793-4

APA

D'Andrea, D., Black, P. C., Zargar, H., Zargar-Shoshtari, K., Soria, F., Fairey, A. S., Mertens, L. S., Dinney, C. P., Mir, M. C., Krabbe, L-M., Cookson, M. S., Jacobsen, N-E., Montgomery, J. S., Vasdev, N., Yu, E. Y., Xylinas, E., Campain, N. J., Kassouf, W., Dall'Era, M. A., ... Shariat, S. F. (2021). Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer. World Journal of Urology. https://doi.org/10.1007/s00345-021-03793-4

Vancouver

Author

D'Andrea, David ; Black, Peter C ; Zargar, Homayoun ; Zargar-Shoshtari, Kamran ; Soria, Francesco ; Fairey, Adrian S ; Mertens, Laura S ; Dinney, Colin P ; Mir, Maria C ; Krabbe, Laura-Maria ; Cookson, Michael S ; Jacobsen, Niels-Erik ; Montgomery, Jeffrey S ; Vasdev, Nikhil ; Yu, Evan Y ; Xylinas, Evanguelos ; Campain, Nicholas J ; Kassouf, Wassim ; Dall'Era, Marc A ; Seah, Jo-An ; Ercole, Cesar E ; Horenblas, Simon ; Sridhar, Srikala S ; McGrath, John S ; Aning, Jonathan ; Wright, Jonathan L ; Thorpe, Andrew C ; Morgan, Todd M ; Holzbeierlein, Jeff M ; Bivalacqua, Trinity J ; North, Scott ; Barocas, Daniel A ; Lotan, Yair ; Grivas, Petros ; Stephenson, Andrew J ; Shah, Jay B ; van Rhijn, Bas W ; Daneshmand, Siamak ; Spiess, Philippe E ; Shariat, Shahrokh F. / Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer. In: World Journal of Urology. 2021.

Bibtex

@article{a70fc6b81fc941898ad8c5cd4105b738,
title = "Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer",
abstract = "PURPOSE: To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).MATERIALS AND METHODS: We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), as well survival outcomes were assessed. We used data of 395 patients from The Cancer Genome Atlas (TCGA) to investigate the prevalence of TCGA molecular subtypes and DNA damage repair (DDR) gene alterations according to patient age.RESULTS: pOR was achieved in 40% of patients. There was no difference in distribution of pOR or pCR between age quartiles. On univariable logistic regression analysis, patient age was not associated with pOR or pCR when evaluated as continuous variables or stratified in quartiles (all p > 0.3). Median follow-up was 18 months (IQR 6-37). On Cox regression and competing risk regression analyses, age was not associated with survival outcomes (all p > 0.05). In the TCGA cohort, patient with age ≤ 60 years has 7% less DDR gene mutations (p = 0.59). We found higher age distribution in patients with luminal (p < 0.001) and luminal infiltrated (p = 0.002) compared to those with luminal papillary subtype.CONCLUSIONS: While younger patients may have less mutational tumor burden, our analysis failed to show an association of age with response to preoperative chemotherapy or survival outcomes. Therefore, the use of preoperative chemotherapy should be considered regardless of patient age.",
author = "David D'Andrea and Black, {Peter C} and Homayoun Zargar and Kamran Zargar-Shoshtari and Francesco Soria and Fairey, {Adrian S} and Mertens, {Laura S} and Dinney, {Colin P} and Mir, {Maria C} and Laura-Maria Krabbe and Cookson, {Michael S} and Niels-Erik Jacobsen and Montgomery, {Jeffrey S} and Nikhil Vasdev and Yu, {Evan Y} and Evanguelos Xylinas and Campain, {Nicholas J} and Wassim Kassouf and Dall'Era, {Marc A} and Jo-An Seah and Ercole, {Cesar E} and Simon Horenblas and Sridhar, {Srikala S} and McGrath, {John S} and Jonathan Aning and Wright, {Jonathan L} and Thorpe, {Andrew C} and Morgan, {Todd M} and Holzbeierlein, {Jeff M} and Bivalacqua, {Trinity J} and Scott North and Barocas, {Daniel A} and Yair Lotan and Petros Grivas and Stephenson, {Andrew J} and Shah, {Jay B} and {van Rhijn}, {Bas W} and Siamak Daneshmand and Spiess, {Philippe E} and Shariat, {Shahrokh F}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
day = "9",
doi = "10.1007/s00345-021-03793-4",
language = "English",
journal = "World Journal of Urology",
issn = "0724-4983",
publisher = "Springer Verlag",

}

RIS

TY - JOUR

T1 - Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer

AU - D'Andrea, David

AU - Black, Peter C

AU - Zargar, Homayoun

AU - Zargar-Shoshtari, Kamran

AU - Soria, Francesco

AU - Fairey, Adrian S

AU - Mertens, Laura S

AU - Dinney, Colin P

AU - Mir, Maria C

AU - Krabbe, Laura-Maria

AU - Cookson, Michael S

AU - Jacobsen, Niels-Erik

AU - Montgomery, Jeffrey S

AU - Vasdev, Nikhil

AU - Yu, Evan Y

AU - Xylinas, Evanguelos

AU - Campain, Nicholas J

AU - Kassouf, Wassim

AU - Dall'Era, Marc A

AU - Seah, Jo-An

AU - Ercole, Cesar E

AU - Horenblas, Simon

AU - Sridhar, Srikala S

AU - McGrath, John S

AU - Aning, Jonathan

AU - Wright, Jonathan L

AU - Thorpe, Andrew C

AU - Morgan, Todd M

AU - Holzbeierlein, Jeff M

AU - Bivalacqua, Trinity J

AU - North, Scott

AU - Barocas, Daniel A

AU - Lotan, Yair

AU - Grivas, Petros

AU - Stephenson, Andrew J

AU - Shah, Jay B

AU - van Rhijn, Bas W

AU - Daneshmand, Siamak

AU - Spiess, Philippe E

AU - Shariat, Shahrokh F

N1 - © 2021. The Author(s).

PY - 2021/8/9

Y1 - 2021/8/9

N2 - PURPOSE: To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).MATERIALS AND METHODS: We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), as well survival outcomes were assessed. We used data of 395 patients from The Cancer Genome Atlas (TCGA) to investigate the prevalence of TCGA molecular subtypes and DNA damage repair (DDR) gene alterations according to patient age.RESULTS: pOR was achieved in 40% of patients. There was no difference in distribution of pOR or pCR between age quartiles. On univariable logistic regression analysis, patient age was not associated with pOR or pCR when evaluated as continuous variables or stratified in quartiles (all p > 0.3). Median follow-up was 18 months (IQR 6-37). On Cox regression and competing risk regression analyses, age was not associated with survival outcomes (all p > 0.05). In the TCGA cohort, patient with age ≤ 60 years has 7% less DDR gene mutations (p = 0.59). We found higher age distribution in patients with luminal (p < 0.001) and luminal infiltrated (p = 0.002) compared to those with luminal papillary subtype.CONCLUSIONS: While younger patients may have less mutational tumor burden, our analysis failed to show an association of age with response to preoperative chemotherapy or survival outcomes. Therefore, the use of preoperative chemotherapy should be considered regardless of patient age.

AB - PURPOSE: To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).MATERIALS AND METHODS: We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), as well survival outcomes were assessed. We used data of 395 patients from The Cancer Genome Atlas (TCGA) to investigate the prevalence of TCGA molecular subtypes and DNA damage repair (DDR) gene alterations according to patient age.RESULTS: pOR was achieved in 40% of patients. There was no difference in distribution of pOR or pCR between age quartiles. On univariable logistic regression analysis, patient age was not associated with pOR or pCR when evaluated as continuous variables or stratified in quartiles (all p > 0.3). Median follow-up was 18 months (IQR 6-37). On Cox regression and competing risk regression analyses, age was not associated with survival outcomes (all p > 0.05). In the TCGA cohort, patient with age ≤ 60 years has 7% less DDR gene mutations (p = 0.59). We found higher age distribution in patients with luminal (p < 0.001) and luminal infiltrated (p = 0.002) compared to those with luminal papillary subtype.CONCLUSIONS: While younger patients may have less mutational tumor burden, our analysis failed to show an association of age with response to preoperative chemotherapy or survival outcomes. Therefore, the use of preoperative chemotherapy should be considered regardless of patient age.

U2 - 10.1007/s00345-021-03793-4

DO - 10.1007/s00345-021-03793-4

M3 - Article

C2 - 34370078

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

ER -