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ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes. / McAuley, W. J.; Lad, M. D.; Mader, K. T.; Santos, P.; Tetteh, J.; Kazarian, S. G.; Hadgraft, J.; Lane, M. E.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 74, No. 2, 02.2010, p. 413-419.

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McAuley, W. J. ; Lad, M. D. ; Mader, K. T. ; Santos, P. ; Tetteh, J. ; Kazarian, S. G. ; Hadgraft, J. ; Lane, M. E. / ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes. In: European Journal of Pharmaceutics and Biopharmaceutics. 2010 ; Vol. 74, No. 2. pp. 413-419.

Bibtex

@article{6fa49f2f421c45709db14682b80fb6d8,
title = "ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes",
abstract = "The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy has been used to monitor the effects of different solvents on the diffusion of a model compound, 4-cyanophenol (CNP) across silicone membrane and on the equilibrium concentration of CNP obtained in the membrane following diffusion. ATR-FTIR spectroscopic imaging of membrane diffusion was used to gain an understanding of when the boundary conditions applied to Fick's second law, used to model the diffusion of permeants across the silicone membrane do not hold. The imaging experiments indicated that when the solvent was not taken up appreciably into the membrane, the presence of discrete solvent pools between the ATR crystal and the silicone membrane can affect the diffusion profile of the permeant. This effect is more significant if the permeant has a high solubility in the solvent. In contrast, solvents that are taken up into the membrane to a greater extent, or those where the solubility of the permeant in the vehicle is relatively low, were found to show a good fit to the diffusion model. As Such these systems allow the ATR-FTIR spectroscopic approach to give mechanistic insight into how the particular solvents enhance permeation. The Solubility of CNP in the solvent and the uptake of the solvent into the membrane were found to be important influences on the equilibrium concentration of the permeant obtained in the membrane following diffusion. In general, solvents which were taken up to a significant extent into the membrane and which Caused the membrane to swell increased the diffusion coefficient of the permeant in the membrane though other factors such as solvent viscosity may also be important. (C) 2009 Elsevier B.V. All rights reserved.",
keywords = "ATR-FTIR spectroscopy, Imaging, Drug transport, Membrane diffusion, Penetration enhancers, HUMAN STRATUM-CORNEUM, SYNTHETIC MEMBRANES, SOLUTE INTERACTIONS, SILICONE MEMBRANES, PERMEABILITY DATA, BENZOIC-ACID, TRANSPORT, CELLS, SKIN",
author = "McAuley, {W. J.} and Lad, {M. D.} and Mader, {K. T.} and P. Santos and J. Tetteh and Kazarian, {S. G.} and J. Hadgraft and Lane, {M. E.}",
year = "2010",
month = feb,
doi = "10.1016/j.ejpb.2009.11.004",
language = "English",
volume = "74",
pages = "413--419",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes

AU - McAuley, W. J.

AU - Lad, M. D.

AU - Mader, K. T.

AU - Santos, P.

AU - Tetteh, J.

AU - Kazarian, S. G.

AU - Hadgraft, J.

AU - Lane, M. E.

PY - 2010/2

Y1 - 2010/2

N2 - The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy has been used to monitor the effects of different solvents on the diffusion of a model compound, 4-cyanophenol (CNP) across silicone membrane and on the equilibrium concentration of CNP obtained in the membrane following diffusion. ATR-FTIR spectroscopic imaging of membrane diffusion was used to gain an understanding of when the boundary conditions applied to Fick's second law, used to model the diffusion of permeants across the silicone membrane do not hold. The imaging experiments indicated that when the solvent was not taken up appreciably into the membrane, the presence of discrete solvent pools between the ATR crystal and the silicone membrane can affect the diffusion profile of the permeant. This effect is more significant if the permeant has a high solubility in the solvent. In contrast, solvents that are taken up into the membrane to a greater extent, or those where the solubility of the permeant in the vehicle is relatively low, were found to show a good fit to the diffusion model. As Such these systems allow the ATR-FTIR spectroscopic approach to give mechanistic insight into how the particular solvents enhance permeation. The Solubility of CNP in the solvent and the uptake of the solvent into the membrane were found to be important influences on the equilibrium concentration of the permeant obtained in the membrane following diffusion. In general, solvents which were taken up to a significant extent into the membrane and which Caused the membrane to swell increased the diffusion coefficient of the permeant in the membrane though other factors such as solvent viscosity may also be important. (C) 2009 Elsevier B.V. All rights reserved.

AB - The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy has been used to monitor the effects of different solvents on the diffusion of a model compound, 4-cyanophenol (CNP) across silicone membrane and on the equilibrium concentration of CNP obtained in the membrane following diffusion. ATR-FTIR spectroscopic imaging of membrane diffusion was used to gain an understanding of when the boundary conditions applied to Fick's second law, used to model the diffusion of permeants across the silicone membrane do not hold. The imaging experiments indicated that when the solvent was not taken up appreciably into the membrane, the presence of discrete solvent pools between the ATR crystal and the silicone membrane can affect the diffusion profile of the permeant. This effect is more significant if the permeant has a high solubility in the solvent. In contrast, solvents that are taken up into the membrane to a greater extent, or those where the solubility of the permeant in the vehicle is relatively low, were found to show a good fit to the diffusion model. As Such these systems allow the ATR-FTIR spectroscopic approach to give mechanistic insight into how the particular solvents enhance permeation. The Solubility of CNP in the solvent and the uptake of the solvent into the membrane were found to be important influences on the equilibrium concentration of the permeant obtained in the membrane following diffusion. In general, solvents which were taken up to a significant extent into the membrane and which Caused the membrane to swell increased the diffusion coefficient of the permeant in the membrane though other factors such as solvent viscosity may also be important. (C) 2009 Elsevier B.V. All rights reserved.

KW - ATR-FTIR spectroscopy

KW - Imaging

KW - Drug transport

KW - Membrane diffusion

KW - Penetration enhancers

KW - HUMAN STRATUM-CORNEUM

KW - SYNTHETIC MEMBRANES

KW - SOLUTE INTERACTIONS

KW - SILICONE MEMBRANES

KW - PERMEABILITY DATA

KW - BENZOIC-ACID

KW - TRANSPORT

KW - CELLS

KW - SKIN

U2 - 10.1016/j.ejpb.2009.11.004

DO - 10.1016/j.ejpb.2009.11.004

M3 - Article

VL - 74

SP - 413

EP - 419

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 2

ER -