University of Hertfordshire

Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Documents

  • Maria Braoudaki
  • Dimitrios-Dionysios Koutsouris
  • Ioannis Kouris
  • Anna Paidi
  • Georgia Koutsouri
  • I George Lambrou
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Original languageEnglish
Title of host publication 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages5834-5837
Number of pages4
DOIs
Publication statusPublished - 29 Oct 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - 2018 - Honolulu, United States
Duration: 18 Jul 201821 Aug 2018

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - 2018
CountryUnited States
CityHonolulu
Period18/07/1821/08/18

Abstract

Pediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. Further on, prognosis of this type of neoplasms still remain poor and the comprehension of the etiology and pathogenesis of the disease still remains scarce. Several reports have identified microRNAs as significant molecules in the development of central nervous system tumors and propose that they might compose key molecules underlying oncogenesis. In a previous study we have identified several miRNAs, common to different subtypes of pediatric embryonal CNS malignancies as well as, we have identified miRNAs that manifest significant dynamics with respect to their expression and the neoplasmatic subtype. Overall, 19 tumor cases from children diagnosed with embryonal brain tumors were investigated. As controls, children who suffered a sudden death underwent autopsy and were not present with any brain malignancy were used (13 samples of varying localization). Our experimental approach included microarrays covering 1211 miRNAs, which appeared to manifest tumor-specific dynamics. In conclusion, it appeared that certain miRNAs are neoplasm specific and in particular, their expression manifests linear dynamics. Thus, the investigation of miRNA expression in pediatric embryonal brain tumors might contribute towards the discovery of tumor-specific miRNA signatures, which could potentially afford the identification of gene-specific biomarkers related to diagnosis, prognosis and patient targeted therapy, as well as help us understand oncogenetic dynamics.

ID: 17661773