University of Hertfordshire

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Blood/plasma secretome and microvesicles

Research output: Contribution to journalReview articlepeer-review

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Blood/plasma secretome and microvesicles. / Inal, Jameel M; Kosgodage, Uchini; Azam, Sarah; Stratton, Dan; Antwi-Baffour, Samuel; Lange, Sigrun.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1834, No. 11, 11.2013, p. 2317-25.

Research output: Contribution to journalReview articlepeer-review

Harvard

Inal, JM, Kosgodage, U, Azam, S, Stratton, D, Antwi-Baffour, S & Lange, S 2013, 'Blood/plasma secretome and microvesicles', Biochimica et Biophysica Acta - Biomembranes, vol. 1834, no. 11, pp. 2317-25. https://doi.org/10.1016/j.bbapap.2013.04.005

APA

Inal, J. M., Kosgodage, U., Azam, S., Stratton, D., Antwi-Baffour, S., & Lange, S. (2013). Blood/plasma secretome and microvesicles. Biochimica et Biophysica Acta - Biomembranes, 1834(11), 2317-25. https://doi.org/10.1016/j.bbapap.2013.04.005

Vancouver

Inal JM, Kosgodage U, Azam S, Stratton D, Antwi-Baffour S, Lange S. Blood/plasma secretome and microvesicles. Biochimica et Biophysica Acta - Biomembranes. 2013 Nov;1834(11):2317-25. https://doi.org/10.1016/j.bbapap.2013.04.005

Author

Inal, Jameel M ; Kosgodage, Uchini ; Azam, Sarah ; Stratton, Dan ; Antwi-Baffour, Samuel ; Lange, Sigrun. / Blood/plasma secretome and microvesicles. In: Biochimica et Biophysica Acta - Biomembranes. 2013 ; Vol. 1834, No. 11. pp. 2317-25.

Bibtex

@article{2c8e859be3da40a79f8059777d87bfd9,
title = "Blood/plasma secretome and microvesicles",
abstract = "A major but hitherto overseen component of the blood/plasma secretome is that of extracellular vesicles (EVs) which are shed from all blood cell types. These EVs are made up of microvesicles (MVs) and exosomes. MVs, 100nm-1μm in diameter, are released from the cell surface, and are a rich source of non-conventionally secreted proteins lacking a conventional signal peptide, and thus not secreted by the classical secretory pathways. Exosomes are smaller vesicles (≤100nm) having an endocytic origin and released upon multivesicular body fusion with the plasma membrane. Both vesicle types play major roles in intercellular cross talk and constitute an important component of the secretome especially in the area of biomarkers for cancer. The release of EVs, which are found in all the bodily fluids, is enhanced in cancer and a major focus of cancer proteomics is therefore targeted at EVs. The blood/plasma secretome is also a source of EVs, potentially diagnostic of infectious disease, whether from EVs released from infected cells or from the pathogens themselves. Despite the great excitement in this field, as is stated here and in other parts of this Special issue entitled: An Updated Secretome, much of the EV research, whether proteomic or functional in nature, urgently needs standardisation both in terms of nomenclature and isolation protocols. This article is part of a Special Issue entitled: An Updated Secretome.",
keywords = "Animals, Cell-Derived Microparticles, Exosomes, Humans, Neoplasms, Protein Sorting Signals, Proteome, Proteomics, Secretory Pathway, Journal Article, Review",
author = "Inal, {Jameel M} and Uchini Kosgodage and Sarah Azam and Dan Stratton and Samuel Antwi-Baffour and Sigrun Lange",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = nov,
doi = "10.1016/j.bbapap.2013.04.005",
language = "English",
volume = "1834",
pages = "2317--25",
journal = "Biochimica et Biophysica Acta - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Blood/plasma secretome and microvesicles

AU - Inal, Jameel M

AU - Kosgodage, Uchini

AU - Azam, Sarah

AU - Stratton, Dan

AU - Antwi-Baffour, Samuel

AU - Lange, Sigrun

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - A major but hitherto overseen component of the blood/plasma secretome is that of extracellular vesicles (EVs) which are shed from all blood cell types. These EVs are made up of microvesicles (MVs) and exosomes. MVs, 100nm-1μm in diameter, are released from the cell surface, and are a rich source of non-conventionally secreted proteins lacking a conventional signal peptide, and thus not secreted by the classical secretory pathways. Exosomes are smaller vesicles (≤100nm) having an endocytic origin and released upon multivesicular body fusion with the plasma membrane. Both vesicle types play major roles in intercellular cross talk and constitute an important component of the secretome especially in the area of biomarkers for cancer. The release of EVs, which are found in all the bodily fluids, is enhanced in cancer and a major focus of cancer proteomics is therefore targeted at EVs. The blood/plasma secretome is also a source of EVs, potentially diagnostic of infectious disease, whether from EVs released from infected cells or from the pathogens themselves. Despite the great excitement in this field, as is stated here and in other parts of this Special issue entitled: An Updated Secretome, much of the EV research, whether proteomic or functional in nature, urgently needs standardisation both in terms of nomenclature and isolation protocols. This article is part of a Special Issue entitled: An Updated Secretome.

AB - A major but hitherto overseen component of the blood/plasma secretome is that of extracellular vesicles (EVs) which are shed from all blood cell types. These EVs are made up of microvesicles (MVs) and exosomes. MVs, 100nm-1μm in diameter, are released from the cell surface, and are a rich source of non-conventionally secreted proteins lacking a conventional signal peptide, and thus not secreted by the classical secretory pathways. Exosomes are smaller vesicles (≤100nm) having an endocytic origin and released upon multivesicular body fusion with the plasma membrane. Both vesicle types play major roles in intercellular cross talk and constitute an important component of the secretome especially in the area of biomarkers for cancer. The release of EVs, which are found in all the bodily fluids, is enhanced in cancer and a major focus of cancer proteomics is therefore targeted at EVs. The blood/plasma secretome is also a source of EVs, potentially diagnostic of infectious disease, whether from EVs released from infected cells or from the pathogens themselves. Despite the great excitement in this field, as is stated here and in other parts of this Special issue entitled: An Updated Secretome, much of the EV research, whether proteomic or functional in nature, urgently needs standardisation both in terms of nomenclature and isolation protocols. This article is part of a Special Issue entitled: An Updated Secretome.

KW - Animals

KW - Cell-Derived Microparticles

KW - Exosomes

KW - Humans

KW - Neoplasms

KW - Protein Sorting Signals

KW - Proteome

KW - Proteomics

KW - Secretory Pathway

KW - Journal Article

KW - Review

U2 - 10.1016/j.bbapap.2013.04.005

DO - 10.1016/j.bbapap.2013.04.005

M3 - Review article

C2 - 23590876

VL - 1834

SP - 2317

EP - 2325

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

SN - 0005-2736

IS - 11

ER -