University of Hertfordshire

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Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications

Research output: Contribution to journalArticlepeer-review

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Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications. / Kemal, Evren; Abelha, Thais Fedatto; Urbano, Laura; Peters, Ruby; Owen, Dylan M.; Howes, P.; Green, Mark; Dailey, Lea Ann.

In: RSC Advances, Vol. 7, No. 25, 07.03.2017, p. 15255-15264.

Research output: Contribution to journalArticlepeer-review

Harvard

Kemal, E, Abelha, TF, Urbano, L, Peters, R, Owen, DM, Howes, P, Green, M & Dailey, LA 2017, 'Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications', RSC Advances, vol. 7, no. 25, pp. 15255-15264. https://doi.org/10.1039/c6ra25004a

APA

Kemal, E., Abelha, T. F., Urbano, L., Peters, R., Owen, D. M., Howes, P., Green, M., & Dailey, L. A. (2017). Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications. RSC Advances, 7(25), 15255-15264. https://doi.org/10.1039/c6ra25004a

Vancouver

Author

Kemal, Evren ; Abelha, Thais Fedatto ; Urbano, Laura ; Peters, Ruby ; Owen, Dylan M. ; Howes, P. ; Green, Mark ; Dailey, Lea Ann. / Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications. In: RSC Advances. 2017 ; Vol. 7, No. 25. pp. 15255-15264.

Bibtex

@article{1a05be79c76d4cb59e6a91467ef6929d,
title = "Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications",
abstract = "Conjugated polymers are of interest as optical imaging probes for clinical diagnostic applications. However, clinical translation requires not only an excellent optical performance, but also an established safety profile and scalable manufacturability. Taking these factors into account, a self-assembling nanoparticle system was designed utilising the amphiphilic diblock copolymer, PLGA-PEG, to encapsulate the red-emitting conjugated polymer, CN-PPV. Encapsulation of decreasing amounts of CN-PPV (50% to 5% w/w) resulted in a decrease in nanoparticle size and an increase in optical performance (quantum yield% ∼40%). All systems were colloidally and optically stable over 60 days at 37 °C. Optimized systems were then used to encapsulate small amounts (0.5-0.8% w/w) of small molecule near-infrared dyes, NIR680 and NIR720, generating systems with shifted emission peaks >700 nm. Optimised PLGA-PEG micelles containing 5% CN-PPV and 0.5% NIR720 showed enhanced characteristics, such as a high product yield (>90%), a narrow emission peak at 720 nm, a high quantum yield of 45%, a small hydrodynamic diameter (∼104 nm), and an enhanced cytocompatibility profile compared to other systems tested in this study, i.e. no reduction in cell viability and negligible impairment of mitochondrial acitivity at higher concentrations.",
author = "Evren Kemal and Abelha, {Thais Fedatto} and Laura Urbano and Ruby Peters and Owen, {Dylan M.} and P. Howes and Mark Green and Dailey, {Lea Ann}",
note = "This journal is {\textcopyright} The Royal Society of Chemistry 2017.",
year = "2017",
month = mar,
day = "7",
doi = "10.1039/c6ra25004a",
language = "English",
volume = "7",
pages = "15255--15264",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "25",

}

RIS

TY - JOUR

T1 - Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications

AU - Kemal, Evren

AU - Abelha, Thais Fedatto

AU - Urbano, Laura

AU - Peters, Ruby

AU - Owen, Dylan M.

AU - Howes, P.

AU - Green, Mark

AU - Dailey, Lea Ann

N1 - This journal is © The Royal Society of Chemistry 2017.

PY - 2017/3/7

Y1 - 2017/3/7

N2 - Conjugated polymers are of interest as optical imaging probes for clinical diagnostic applications. However, clinical translation requires not only an excellent optical performance, but also an established safety profile and scalable manufacturability. Taking these factors into account, a self-assembling nanoparticle system was designed utilising the amphiphilic diblock copolymer, PLGA-PEG, to encapsulate the red-emitting conjugated polymer, CN-PPV. Encapsulation of decreasing amounts of CN-PPV (50% to 5% w/w) resulted in a decrease in nanoparticle size and an increase in optical performance (quantum yield% ∼40%). All systems were colloidally and optically stable over 60 days at 37 °C. Optimized systems were then used to encapsulate small amounts (0.5-0.8% w/w) of small molecule near-infrared dyes, NIR680 and NIR720, generating systems with shifted emission peaks >700 nm. Optimised PLGA-PEG micelles containing 5% CN-PPV and 0.5% NIR720 showed enhanced characteristics, such as a high product yield (>90%), a narrow emission peak at 720 nm, a high quantum yield of 45%, a small hydrodynamic diameter (∼104 nm), and an enhanced cytocompatibility profile compared to other systems tested in this study, i.e. no reduction in cell viability and negligible impairment of mitochondrial acitivity at higher concentrations.

AB - Conjugated polymers are of interest as optical imaging probes for clinical diagnostic applications. However, clinical translation requires not only an excellent optical performance, but also an established safety profile and scalable manufacturability. Taking these factors into account, a self-assembling nanoparticle system was designed utilising the amphiphilic diblock copolymer, PLGA-PEG, to encapsulate the red-emitting conjugated polymer, CN-PPV. Encapsulation of decreasing amounts of CN-PPV (50% to 5% w/w) resulted in a decrease in nanoparticle size and an increase in optical performance (quantum yield% ∼40%). All systems were colloidally and optically stable over 60 days at 37 °C. Optimized systems were then used to encapsulate small amounts (0.5-0.8% w/w) of small molecule near-infrared dyes, NIR680 and NIR720, generating systems with shifted emission peaks >700 nm. Optimised PLGA-PEG micelles containing 5% CN-PPV and 0.5% NIR720 showed enhanced characteristics, such as a high product yield (>90%), a narrow emission peak at 720 nm, a high quantum yield of 45%, a small hydrodynamic diameter (∼104 nm), and an enhanced cytocompatibility profile compared to other systems tested in this study, i.e. no reduction in cell viability and negligible impairment of mitochondrial acitivity at higher concentrations.

UR - http://www.scopus.com/inward/record.url?scp=85014763744&partnerID=8YFLogxK

U2 - 10.1039/c6ra25004a

DO - 10.1039/c6ra25004a

M3 - Article

AN - SCOPUS:85014763744

VL - 7

SP - 15255

EP - 15264

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 25

ER -