University of Hertfordshire

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Centrosomin represses dendrite branching by orienting microtubule nucleation

Research output: Contribution to journalArticlepeer-review


  • Cagri Yalgin
  • Saman Ebrahimi
  • Caroline Delandre
  • Li Foong Yoong
  • Saori Akimoto
  • Heidi Tran
  • Reiko Amikura
  • Rebecca Spokony
  • Ben Torben-Nielsen
  • Kevin P. White
  • Adrian W. Moore
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Original languageEnglish
Pages (from-to)1437-45
Number of pages9
JournalNature Neuroscience
Early online date31 Aug 2015
Publication statusPublished - 1 Oct 2015


Neuronal dendrite branching is fundamental for building nervous systems. Branch formation is genetically encoded by transcriptional programs to create dendrite arbor morphological diversity for complex neuronal functions. In Drosophila sensory neurons, the transcription factor Abrupt represses branching via an unknown effector pathway. Targeted screening for branching-control effectors identified Centrosomin, the primary centrosome-associated protein for mitotic spindle maturation. Centrosomin repressed dendrite branch formation and was used by Abrupt to simplify arbor branching. Live imaging revealed that Centrosomin localized to the Golgi cis face and that it recruited microtubule nucleation to Golgi outposts for net retrograde microtubule polymerization away from nascent dendrite branches. Removal of Centrosomin enabled the engagement of wee Augmin activity to promote anterograde microtubule growth into the nascent branches, leading to increased branching. The findings reveal that polarized targeting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule polymerization.


This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nature Neuroscience, after peer review and technical editing by the publisher. To access the final edited work see:, doi:10.1038/nn.4099.

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