University of Hertfordshire

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Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors. / Reichen, M.; Super, A.; Davies, M. J.; Macown, R. J.; O'Sullivan, B.; Kirk, T. V.; Marques, M. P.C.; Dimov, N.; Szita, N.

In: Chemical and Biochemical Engineering Quarterly, Vol. 28, No. 2, 2014, p. 189-202.

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APA

Reichen, M., Super, A., Davies, M. J., Macown, R. J., O'Sullivan, B., Kirk, T. V., Marques, M. P. C., Dimov, N., & Szita, N. (2014). Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors. Chemical and Biochemical Engineering Quarterly, 28(2), 189-202. https://doi.org/10.15255/CABEQ.2014.1937

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Author

Reichen, M. ; Super, A. ; Davies, M. J. ; Macown, R. J. ; O'Sullivan, B. ; Kirk, T. V. ; Marques, M. P.C. ; Dimov, N. ; Szita, N. / Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors. In: Chemical and Biochemical Engineering Quarterly. 2014 ; Vol. 28, No. 2. pp. 189-202.

Bibtex

@article{ebd758a468d14364b63527e6a063338a,
title = "Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors",
abstract = "The development of microfluidic devices is an iterative process that involves series of improvements, which can be costly and time consuming. We present a packaging system which makes use of an accessible rapid prototyping method, and facilitates the rapid and reliable implementation of polymeric microfluidic device designs. The packaging system uses a modular design and is based on an adhesive-free connection of a reusable and stiff polymeric interface plate with a disposable, soft microfluidic chip under compression. We characterised the system by numerically and experimentally studying the effect of compression and key dimensions on burst pressure and flow rate. All parts are fabricated with readily available low-cost materials and micro-milling technology. The presented approach is both facilitating and systematising the fabrication of devices with different degrees of complexity; keeping assembly and interconnection simple and straightforward. Furthermore, minimising the time between a design and a finished working prototype yields rapid verification of microfluidic design concepts and testing of assays. Several chip designs were fabricated, then growth of stem cells and hydrodynamic vertical flow focusing in a microfluidic device were realised using our approach. Our approach minimises the need for re-development and re-testing of interface components; reducing cost and time requirements.",
keywords = "Hydrodynamic vertical flow focussing, Micro milling, Micro reactors, Packaging, Rapid prototyping, Stem cell culture",
author = "M. Reichen and A. Super and Davies, {M. J.} and Macown, {R. J.} and B. O'Sullivan and Kirk, {T. V.} and Marques, {M. P.C.} and N. Dimov and N. Szita",
year = "2014",
doi = "10.15255/CABEQ.2014.1937",
language = "English",
volume = "28",
pages = "189--202",
journal = "Chemical and Biochemical Engineering Quarterly",
issn = "0352-9568",
publisher = "Assoc. of Chemists and Chemical Engineers of Croatia",
number = "2",

}

RIS

TY - JOUR

T1 - Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors

AU - Reichen, M.

AU - Super, A.

AU - Davies, M. J.

AU - Macown, R. J.

AU - O'Sullivan, B.

AU - Kirk, T. V.

AU - Marques, M. P.C.

AU - Dimov, N.

AU - Szita, N.

PY - 2014

Y1 - 2014

N2 - The development of microfluidic devices is an iterative process that involves series of improvements, which can be costly and time consuming. We present a packaging system which makes use of an accessible rapid prototyping method, and facilitates the rapid and reliable implementation of polymeric microfluidic device designs. The packaging system uses a modular design and is based on an adhesive-free connection of a reusable and stiff polymeric interface plate with a disposable, soft microfluidic chip under compression. We characterised the system by numerically and experimentally studying the effect of compression and key dimensions on burst pressure and flow rate. All parts are fabricated with readily available low-cost materials and micro-milling technology. The presented approach is both facilitating and systematising the fabrication of devices with different degrees of complexity; keeping assembly and interconnection simple and straightforward. Furthermore, minimising the time between a design and a finished working prototype yields rapid verification of microfluidic design concepts and testing of assays. Several chip designs were fabricated, then growth of stem cells and hydrodynamic vertical flow focusing in a microfluidic device were realised using our approach. Our approach minimises the need for re-development and re-testing of interface components; reducing cost and time requirements.

AB - The development of microfluidic devices is an iterative process that involves series of improvements, which can be costly and time consuming. We present a packaging system which makes use of an accessible rapid prototyping method, and facilitates the rapid and reliable implementation of polymeric microfluidic device designs. The packaging system uses a modular design and is based on an adhesive-free connection of a reusable and stiff polymeric interface plate with a disposable, soft microfluidic chip under compression. We characterised the system by numerically and experimentally studying the effect of compression and key dimensions on burst pressure and flow rate. All parts are fabricated with readily available low-cost materials and micro-milling technology. The presented approach is both facilitating and systematising the fabrication of devices with different degrees of complexity; keeping assembly and interconnection simple and straightforward. Furthermore, minimising the time between a design and a finished working prototype yields rapid verification of microfluidic design concepts and testing of assays. Several chip designs were fabricated, then growth of stem cells and hydrodynamic vertical flow focusing in a microfluidic device were realised using our approach. Our approach minimises the need for re-development and re-testing of interface components; reducing cost and time requirements.

KW - Hydrodynamic vertical flow focussing

KW - Micro milling

KW - Micro reactors

KW - Packaging

KW - Rapid prototyping

KW - Stem cell culture

UR - http://www.scopus.com/inward/record.url?scp=84899838226&partnerID=8YFLogxK

U2 - 10.15255/CABEQ.2014.1937

DO - 10.15255/CABEQ.2014.1937

M3 - Article

AN - SCOPUS:84899838226

VL - 28

SP - 189

EP - 202

JO - Chemical and Biochemical Engineering Quarterly

JF - Chemical and Biochemical Engineering Quarterly

SN - 0352-9568

IS - 2

ER -