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Complement C2 receptor inhibitor trispanning: from man to schistosome

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Complement C2 receptor inhibitor trispanning : from man to schistosome. / Inal, Jameel M.

In: Springer seminars in immunopathology, Vol. 27, No. 3, 11.2005, p. 320-31.

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@article{bdc880310a8c4458bec6320651351abc,
title = "Complement C2 receptor inhibitor trispanning: from man to schistosome",
abstract = "Horizontal gene transfer (HGT), in relation to genetic transfer between hosts and parasites, is a little described mechanism. Since the complement inhibitor CRIT was first discovered in the human Schistosoma parasite (the causative agent of Bilharzia) and in Trypanosoma cruzi (a parasite causing Chagas' disease), it has been found to be distributed amongst various species, ranging from the early teleost cod to rats and humans. In terms of evolutionary distance, as measured in a phylogenetic analysis of these CRIT genes at nucleotide level, the parasitic species are as removed from their human host as is the rat sequence, suggesting HGT. The hypotheses that CRIT in humans and schistosomes is orthologous and that the presence of CRIT in schistosomes occurs as a result of host-to-parasite HGT are presented in the light of empirical data and the growing body of data on mobile genetic elements in human and schistosome genomes. In summary, these data indicate phylogenetic proximity between Schistosoma and human CRIT, identity of function, high nucleotide/amino acid identity and secondary protein structure, as well as identical genomic organization.",
keywords = "Amino Acid Sequence, Animals, Antigens, Helminth, Carrier Proteins, Complement System Proteins, Gadus morhua, Gene Transfer, Horizontal, Helminth Proteins, Humans, Models, Molecular, Molecular Sequence Data, Phylogeny, Rats, Receptors, Cell Surface, Schistosoma, Sequence Homology, Amino Acid, Journal Article, Review",
author = "Inal, {Jameel M}",
year = "2005",
month = nov,
doi = "10.1007/s00281-005-0009-9",
language = "English",
volume = "27",
pages = "320--31",
journal = "Springer seminars in immunopathology",
issn = "0344-4325",
publisher = "Springer Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - Complement C2 receptor inhibitor trispanning

T2 - from man to schistosome

AU - Inal, Jameel M

PY - 2005/11

Y1 - 2005/11

N2 - Horizontal gene transfer (HGT), in relation to genetic transfer between hosts and parasites, is a little described mechanism. Since the complement inhibitor CRIT was first discovered in the human Schistosoma parasite (the causative agent of Bilharzia) and in Trypanosoma cruzi (a parasite causing Chagas' disease), it has been found to be distributed amongst various species, ranging from the early teleost cod to rats and humans. In terms of evolutionary distance, as measured in a phylogenetic analysis of these CRIT genes at nucleotide level, the parasitic species are as removed from their human host as is the rat sequence, suggesting HGT. The hypotheses that CRIT in humans and schistosomes is orthologous and that the presence of CRIT in schistosomes occurs as a result of host-to-parasite HGT are presented in the light of empirical data and the growing body of data on mobile genetic elements in human and schistosome genomes. In summary, these data indicate phylogenetic proximity between Schistosoma and human CRIT, identity of function, high nucleotide/amino acid identity and secondary protein structure, as well as identical genomic organization.

AB - Horizontal gene transfer (HGT), in relation to genetic transfer between hosts and parasites, is a little described mechanism. Since the complement inhibitor CRIT was first discovered in the human Schistosoma parasite (the causative agent of Bilharzia) and in Trypanosoma cruzi (a parasite causing Chagas' disease), it has been found to be distributed amongst various species, ranging from the early teleost cod to rats and humans. In terms of evolutionary distance, as measured in a phylogenetic analysis of these CRIT genes at nucleotide level, the parasitic species are as removed from their human host as is the rat sequence, suggesting HGT. The hypotheses that CRIT in humans and schistosomes is orthologous and that the presence of CRIT in schistosomes occurs as a result of host-to-parasite HGT are presented in the light of empirical data and the growing body of data on mobile genetic elements in human and schistosome genomes. In summary, these data indicate phylogenetic proximity between Schistosoma and human CRIT, identity of function, high nucleotide/amino acid identity and secondary protein structure, as well as identical genomic organization.

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, Helminth

KW - Carrier Proteins

KW - Complement System Proteins

KW - Gadus morhua

KW - Gene Transfer, Horizontal

KW - Helminth Proteins

KW - Humans

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Phylogeny

KW - Rats

KW - Receptors, Cell Surface

KW - Schistosoma

KW - Sequence Homology, Amino Acid

KW - Journal Article

KW - Review

U2 - 10.1007/s00281-005-0009-9

DO - 10.1007/s00281-005-0009-9

M3 - Review article

C2 - 16235057

VL - 27

SP - 320

EP - 331

JO - Springer seminars in immunopathology

JF - Springer seminars in immunopathology

SN - 0344-4325

IS - 3

ER -